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Cholestatic liver diseases: modern therapeutics
Bridgette B McNally1, Elizabeth J Carey1
1Mayo Clinic Arizona, Department of Gastroenterology & Hepatology, Division of Hepatology, Phoenix, Arizona, USA.
Expert Review of Gastroenterology & Hepatology
|February 26, 2025
Summary
Updates in managing autoimmune cholestatic liver diseases like primary biliary cholangitis (PBC) and primary sclerosing cholangitis (PSC) include new therapies beyond ursodeoxycholic acid (UDCA) and ongoing clinical trials for PSC.
Area of Science:
- Hepatology
- Autoimmune Liver Diseases
- Cholestatic Liver Disease
Background:
- Cholestatic liver diseases impair bile flow, causing fatigue, jaundice, and pruritus.
- Primary biliary cholangitis (PBC) and primary sclerosing cholangitis (PSC) are autoimmune cholestatic conditions.
- Current management for PBC includes ursodeoxycholic acid (UDCA), with obeticholic acid (OCA) as an option for suboptimal response.
Conclusions:
- Continued investigation into novel treatments for PBC and PSC is crucial.
- Alternative management strategies for both conditions are expected to emerge in the next 5-10 years.
- The evolving therapeutic landscape offers hope for improved patient outcomes in cholestatic liver diseases.
Keywords:
Cholestatic liver diseasecholestasishepatologyprimary biliary cholangitisprimary sclerosing cholangitisMore Related Videos
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