Related Experiment Video
Updated: May 25, 2025
08:55
The Colon-26 Carcinoma Tumor-bearing Mouse as a Model for the Study of Cancer Cachexia
Published on: November 30, 2016
16.1K
Multicomponent Interventions for Adults With Cancer Cachexia: A Systematic Review.
Megan Bowers1, Carmine Petrasso1, Amy McLuskie2
1Cicely Saunders Institute of Palliative Care, Policy & Rehabilitation, Florence Nightingale Faculty of Nursing, Midwifery & Palliative Care, King's College London, London, UK.
Journal of Cachexia, Sarcopenia and Muscle
|February 27, 2025
Summary
Multicomponent interventions for cancer cachexia show promise for improving quality of life, but few target all key features or compare against usual care. More research is needed to understand optimal tailoring and effectiveness.
Area of Science:
- Oncology
- Palliative Care
- Rehabilitation Medicine
Background:
- Cancer cachexia significantly impairs patient quality of life.
- Current treatments lack a gold standard due to complex pathophysiology.
- A multitargeted, individualized approach is necessary for effective management.
Purpose of the Study:
- To evaluate multicomponent interventions for cancer cachexia.
- To assess the targeting of key cachexia features and individual tailoring.
- To determine the impact on patient quality of life.
Main Methods:
- Systematic review of 62 multicomponent interventions for adult cancer cachexia.
- Classified interventions by category, targeted cachexia features, and tailoring level.
- Analyzed quality of life outcomes using standardized mean changes and differences.
Main Results:
- Most interventions were tailored, but few targeted all four cachexia features.
- Quality of life improved in 11 of 13 studies with high risk of bias.
- Three of four studies comparing interventions to usual care showed improved quality of life.
Conclusions:
- Multicomponent interventions vary in targeting cachexia features and tailoring.
- Limited studies compare interventions to usual care, hindering definitive conclusions.
- High risk of bias and heterogeneity challenge the interpretability of current findings.
Related Concept Videos
01:29Nursing Interventions II: Selecting and Classifying the Nursing Interventions
2.0K
Creating and executing a nursing diagnosis helps nurses plan care and guide patient, family, and community interventions. They are developed based on a patient's physical evaluation and support measuring the outcomes. It is not recommended to select random interventions throughout the planning process. Instead, consider the following six essential factors when choosing interventions:
2.0K
02:59Cancer Prevention
6.0K
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Some...
6.0K
01:21Cancer Survival Analysis
320
Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
320
01:03Nursing Interventions I: Taxonomy of Nursing Interventions
2.4K
Nursing interventions are chosen as part of the planning process to achieve patient outcomes. Once nursing diagnoses are determined, the goals and outcomes are specified, then the nursing interventions are selected and individualized according to the patient's situation.
A nursing intervention is a treatment or action based on scientific concepts and knowledge from the nursing, behavioral, and physical sciences. Identifying and prioritizing nursing interventions based on the desired outcome...
A nursing intervention is a treatment or action based on scientific concepts and knowledge from the nursing, behavioral, and physical sciences. Identifying and prioritizing nursing interventions based on the desired outcome...
2.4K
02:49Cancer Therapies
7.5K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
7.5K
01:29Chronic Pancreatitis II: Collaborative Care
56
The management of chronic pancreatitis is multifaceted, involving a comprehensive approach that includes thorough assessment, diagnostic testing, and a variety of management strategies.
Assessment:
Assessment:
56