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De-risking transformative microscopy technologies for broad adoption
Jesse Aaron1, Teng-Leong Chew1
1Advanced Imaging Center, Howard Hughes Medical Institute Janelia Research Campus, Ashburn, Virginia.
Journal of Microscopy
|February 27, 2025
Summary
New optical microscopy technologies offer biological insights but face adoption hurdles. Open-access incubators can de-risk these innovations, accelerating scientific discovery.
Area of Science:
- Life Sciences
- Biotechnology
- Optical Microscopy
Background:
- Significant advancements in optical microscopy over the past 20 years.
- Limited adoption of novel microscopy technologies within the life science community.
- Challenges to adoption are not solely technical but involve various risks.
Purpose of the Study:
- To identify and address the barriers hindering the widespread adoption of innovative microscopy technologies.
- To propose a framework for de-risking and facilitating the integration of disruptive microscopy inventions.
- To enable transformative scientific output through enhanced technology adoption.
Main Methods:
- Analysis of adoption patterns for new microscopy technologies.
- Identification of common risks associated with disruptive scientific tools.
- Conceptualization of an open-access technology incubator model.
- Development of a framework for technology shepherdin
Main Results:
- Novel microscopy technologies often face significant adoption risks beyond technical utility.
- Open-access technology incubators provide a viable model for mitigating these risks.
- A structured framework can guide innovative microscopy techniques through the adoption process.
Conclusions:
- Addressing adoption challenges is crucial for realizing the full potential of advanced microscopy.
- Open-access incubators are key to de-risking and accelerating the integration of new technologies.
- Implementing a strategic framework will foster transformative scientific advancements through microscopy.

