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Merkel Cell Polyomavirus Infection and Detection
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Genetic and molecular profiling in Merkel Cell Carcinoma: Focus on MCPyV oncoproteins and emerging diagnostic

Harpreet Singh1, Sourav Mohanto2, Anil Kumar3

  • 1School of Pharmaceutical Sciences, IFTM University, Moradabad, Uttar Pradesh 244102, India.

Pathology, Research and Practice
|March 1, 2025
PubMed
Summary

Merkel Cell Carcinoma (MCC), a rare skin cancer, is strongly associated with Merkel cell polyomavirus (MCPyV). Research highlights MCPyV

Keywords:
CancerImmunohistochemistryMCPyVMerkel Cell CarcinomaNext-generation sequencingPolymerase Chain Reaction

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Area of Science:

  • Oncology and Virology: Investigating the intersection of skin cancer pathogenesis and viral etiology.

Background:

  • Merkel Cell Carcinoma (MCC) is an aggressive skin malignancy.
  • Merkel cell polyomavirus (MCPyV) is frequently implicated in MCC development.
  • Understanding the molecular mechanisms linking MCPyV to MCC is crucial for effective treatment.

Purpose of the Study:

  • To provide a comprehensive review of MCC research from 2000-2024.
  • To consolidate knowledge on MCPyV's role in MCC pathogenesis.
  • To highlight advancements in diagnostic and therapeutic strategies targeting viral oncoproteins.

Main Methods:

  • Systematic literature review utilizing keywords: MCC, MCPyV Oncoproteins, Immunohistochemistry, Southern Blot, Western Blot, Polymerase Chain Reaction (PCR), Digital Droplet PCR (ddPCR), Next-Generation Sequencing (NGS), and In Situ Hybridization (ISH).
  • Searches conducted across Google, PubMed Central, Scopus, and ScienceDirect.
  • Analysis of data focusing on genetic and molecular profiling, diagnostic techniques, and therapeutic targets.

Main Results:

  • Consolidated two decades of research on MCC and MCPyV.
  • Detailed the utility of various molecular diagnostic techniques (PCR, ddPCR, NGS, ISH) in MCC.
  • Identified therapeutic potential in targeting MCPyV oncoproteins.

Conclusions:

  • Emphasizes the critical role of MCPyV in MCC pathogenesis.
  • Underscores the importance of molecular diagnostics for early detection and personalized treatment.
  • Suggests that targeting viral oncoproteins offers promising therapeutic avenues for MCC patients.