Related Experiment Video
Updated: May 24, 2025

09:29
Investigating Drivers of Antireward in Addiction Behavior with Anatomically Specific Single-Cell Gene Expression Methods
Published on: August 4, 2022
2.1K
National consensus statement on opioid agonist treatment in custodial settings
Jocelyn Chan1,2,3, Jon Cook2,4, Michael Curtis1,3
1Burnet Institute, Melbourne, VIC.
The Medical Journal of Australia
|March 2, 2025
Summary
Opioid agonist treatment (OAT) in prisons needs improvement. This study provides 19 recommendations for better OAT access and continuity, aiming to reduce overdose deaths for incarcerated individuals.
Area of Science:
- Public Health
- Addiction Medicine
- Criminal Justice Health
Background:
- Opioid use disorder is common in incarcerated populations, leading to high overdose risks.
- Opioid agonist treatment (OAT) is effective but access in prisons is inconsistent.
- There's a national policy gap regarding OAT in Australian prisons.
Purpose of the Study:
- To develop evidence-based recommendations for optimizing OAT in Australian prisons.
- To improve the quality, consistency, and continuity of OAT for incarcerated individuals.
- To address the leading cause of death post-release: overdose.
Main Methods:
- A modified Delphi study was conducted with a national multidisciplinary expert panel.
- 19 recommendations were developed covering five core domains.
- Recommendations were finalized in July 2024.
Main Results:
- Recommendations address OAT induction/continuation, administration, and community transition.
- Key findings include prompt opioid withdrawal management and linkage to community OAT.
- Emphasis on organizational support, funding, and monitoring is crucial.
Conclusions:
- Implementing these recommendations will enhance OAT quality and consistency.
- Improved OAT provision is vital for better health outcomes and reduced overdose deaths.
- This consensus statement provides best practice standards for OAT in Australian prisons.
Related Concept Videos
Analgesia and Pain Management
422
Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
422
Opioid Analgesics: Synthetic and Semisynthetic Opioids
204
Synthetic and semisynthetic opioids are pivotal in pain management and tackling opioid addiction. Semisynthetic opioids, including morphinans (morphine derivatives), oxycodone, oxymorphone, hydrocodone, and hydromorphone, have improved pharmacokinetic profiles compared to morphine. Additionally, heroin and 6-MAM (6-Monoacetylmorphine) show better CNS penetration than morphine due to heightened lipid solubility. Hydromorphone, a potent opioid, undergoes hepatic metabolism to form the active...
204
Drug Abuse and Addiction: Pharmacological Phenomena
422
Drug dependence, abuse, and addiction are complex phenomena that can precipitate various abnormal states. Physical dependence refers to a state of pharmacological adaptation to a drug. This adaptation often results in tolerance—a reduced response to the drug after repeated administrations. When the drug use is abruptly stopped, withdrawal symptoms occur due to the body's need to readjust from the pharmacologically induced imbalance. However, tolerance and withdrawal symptoms do not...
422
Opioid Receptors: Overview
422
Opioid receptors, including the mu (μ, MOR), delta (δ, DOR), and kappa (κ, KOR) types, belong to the rhodopsin family of G protein-coupled receptors. These receptors are located throughout the central and peripheral nervous systems and in non-neuronal tissues such as macrophages and astrocytes. Opioid receptor ligands can be categorized into agonists or antagonists. Highly selective agonists include [d-Ala2, MePhe4, Gly(ol)5]-enkephalin or DAMGO for MOR, [D-Pen2,...
422
Drug Dosage Regimen: Overview
3.4K
A drug dosage regimen describes the specific instructions and schedule for administering a drug to a patient. It considers factors such as drug dosage, frequency, route of administration, and duration of treatment. Designing an appropriate dosage regimen for a patient aims to achieve a target drug concentration at the site of action.
Typically, the starting dose and dosing interval are guided by the manufacturer's recommendations based on clinical trials conducted during and after drug...
Typically, the starting dose and dosing interval are guided by the manufacturer's recommendations based on clinical trials conducted during and after drug...
3.4K
Drug Dependence
965
Medications are typically administered to achieve therapeutic effects. Some drugs can modify an individual's mood and perception, frequently resulting in various enjoyable experiences. However, this can result in drug dependency, a condition marked by continuous drug use despite potential negative consequences. Drug dependency primarily falls into two categories: psychological and physical dependence. Psychological dependence occurs when the pleasurable feelings induced by the drug...
965

