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Related Experiment Video

Updated: May 24, 2025

3D Planning and Printing of Patient Specific Implants for Reconstruction of Bony Defects
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3D printing in musculoskeletal interface engineering: Current progress and future directions.

Tianpeng Xu1, Jingdong Rao1, Yongyi Mo1

  • 1Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong Special Administrative Region.

Advanced Drug Delivery Reviews
|March 3, 2025
PubMed
Summary

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This summary is machine-generated.

Three-dimensional (3D) printing offers advanced biomimetic scaffolds for musculoskeletal tissue regeneration, addressing limitations of traditional treatments for injuries and diseases. This technology enables precise fabrication for improved integration and functionality at critical tissue interfaces.

Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Orthopedic Medicine

Background:

  • Musculoskeletal tissue interfaces are vital for function but often damaged by injury and disease.
  • Traditional treatments struggle with complex interface restoration.
  • Three-dimensional (3D) printing emerges as a promising solution for fabricating biomimetic scaffolds.

Purpose of the Study:

  • To review the application of 3D printing in creating scaffolds for musculoskeletal tissue interfaces.
  • To highlight advanced techniques like multi-material printing, bioprinting, and 4D printing.
  • To discuss challenges and future prospects for clinical translation.

Main Methods:

  • Review of state-of-the-art 3D printing technologies (extrusion, inkjet, laser-assisted bioprinting).
Keywords:
3D printingBiomaterialsDrug deliveryMusculoskeletal interfaceRegenerative medicineScaffoldsTissue engineering

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  • Emphasis on mimicking natural tissue gradients and biomaterial selection.
  • Discussion of applications in cartilage-bone, intervertebral disc, tendon/ligament-bone, and muscle-tendon junction engineering.

    • Main Results:

    • 3D printing enables precise fabrication of scaffolds with tailored mechanical and biological properties.
    • Advanced techniques facilitate the creation of complex structures mimicking natural tissue gradients.
    • Successful applications demonstrated potential for improved integration and functionality in various musculoskeletal interfaces.

    Conclusions:

    • 3D printing holds transformative potential for orthopedic medicine and tissue regeneration.
    • Addressing challenges in material development, printing resolution, and in vivo performance is crucial for clinical translation.
    • Future research directions include integrating biomaterials, drug delivery, and advanced printing techniques.