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Updated: May 24, 2025
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Brain-Computer Interface-controlled Upper Limb Robotic System for Enhancing Daily Activities in Stroke Patients
Published on: April 18, 2025
217
Effects of brain-computer interface based training on post-stroke upper-limb rehabilitation: a meta-analysis
Dan Li1,2, Ruoyu Li1,3, Yunping Song1,3
1Department of Neurology and Neurological Rehabilitation, Shanghai Disabled Persons' Federation Key Laboratory of Intelligent Rehabilitation Assistive Devices and Technologies, Shanghai Yangzhi Rehabilitation Hospital (Shanghai Sunshine Rehabilitation Center), School of Medicine, , Tongji University, Shanghai, 201619, China.
Journal of Neuroengineering and Rehabilitation
|March 3, 2025
Summary
Brain-computer interface (BCI) training significantly improves upper-limb motor function after stroke. This meta-analysis confirms BCI
Area of Science:
- Neuroscience
- Rehabilitation Medicine
- Biomedical Engineering
Background:
- Previous studies on brain-computer interface (BCI) for upper-limb motor rehabilitation yielded variable results, necessitating a clearer understanding of its efficacy.
- The PROSPERO registration ID for this review is CRD42022383390.
Purpose of the Study:
- To systematically evaluate the effectiveness of BCI-based training in enhancing post-stroke upper-limb motor function.
- To identify factors influencing the outcomes of BCI-based upper-limb rehabilitation programs.
Main Methods:
- A meta-analysis was conducted on randomized controlled trials (RCTs) investigating BCI training for post-stroke upper-limb motor rehabilitation.
- Searches were performed in PubMed, Cochrane Library, and Web of Science up to September 15, 2024.
- The Fugl-Meyer Assessment-Upper Extremity (FMA-UE) was the primary outcome measure, analyzed using RevMan 5.4.1 with a random effects model.
Main Results:
- Twenty-one RCTs involving 886 patients were analyzed. BCI training significantly improved FMA-UE (MD=3.69, P<0.00001), Wolf Motor Function Test (WMFT) (MD=5.00, P=0.0006), and Action Research Arm Test (ARAT) (MD=2.04, P=0.03).
- BCI training demonstrated efficacy in both subacute (FMA-UE: MD=4.24, P=0.0006) and chronic stroke patients (FMA-UE: MD=2.63, P<0.00001).
- Combinations of BCI with functional electrical stimulation (FES), robots, and visual feedback showed significant improvements in FMA-UE, particularly BCI+FES in both subacute and chronic phases.
Conclusions:
- BCI-based training emerges as a dependable strategy for improving upper-limb motor impairment and functional recovery in stroke survivors.
- Optimal rehabilitation outcomes may be associated with daily training sessions of 20-90 minutes, 2-5 times per week for 3-4 weeks.
