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Dry Powder Inhaler of Sustained-Release Microspheres Containing Glycyrrhizin: Factorial Design and Optimization
Arpita Chakraborty1,2, Riya Mahar1, Nidhi Nainwal3
1School of Pharmaceutical Sciences and Technology, Sardar Bhagwan Singh University, Balawala, Dehradun, Uttarakhand 248161, India.
Combinatorial Chemistry & High Throughput Screening
|March 4, 2025
Summary
This study developed inhalable glycyrrhizin microspheres for asthma treatment. The optimized formulation provides sustained drug release in the lungs, offering a promising alternative to corticosteroids.
Area of Science:
- Pharmacology
- Drug Delivery Systems
- Respiratory Medicine
Background:
- Glycyrrhizin, a liquorice plant glycoside, is used for respiratory issues.
- Inhalable glycyrrhizin offers a potential alternative to inhaled corticosteroids, mitigating their long-term side effects.
Purpose of the Study:
- To design and develop inhalable glycyrrhizin microspheres for effective asthma treatment.
- To address the slow drug development rate in respiratory diseases.
Main Methods:
- A 32 full factorial design was employed to optimize polycaprolactone and polyvinyl alcohol concentrations.
- Dependent variables included drug loading and entrapment efficiency.
Main Results:
- Optimized microspheres were spherical, 1-5 μm in size, with a 78% fine particle fraction suitable for inhalation.
- Achieved drug loading of 9.8% and encapsulation efficiency of 40.98%.
- Formulation blended with lactose demonstrated improved lung deposition.
Conclusions:
- Optimized glycyrrhizin microspheres prolonged lung drug residency over 12 hours.
- Inhalable microspheres ensure sustained drug release and protect against pulmonary degradation.
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