The New HLA-B*38:114 Allele Characterised by Two Different Sequencing-Based Typing Techniques
Thomas Morel1, Michaël Pérès1, Sandra Clément1
1HLA and Histocompatibility Laboratory, CHRU de Nancy, Vandœuvre-lès-Nancy, France.
HLA
|March 4, 2025
Summary
A novel human leukocyte antigen (HLA) allele, HLA-B*38:114, has been identified. This new allele is distinguished from HLA-B*38:32 by three specific nucleotide substitutions within exon 3.
Area of Science:
- Immunogenetics
- Molecular Biology
Background:
- Human leukocyte antigen (HLA) genes are crucial for immune response.
- Allelic variations within HLA loci contribute to immune system diversity.
Purpose of the Study:
- To report the discovery and initial characterization of a new HLA-B allele.
Main Methods:
- Nucleotide sequencing of the HLA-B gene.
- Comparative analysis of DNA sequences.
Main Results:
- Identification of a novel allele designated HLA-B*38:114.
- Determination of three nucleotide differences in exon 3 compared to HLA-B*38:32.
Conclusions:
- The newly identified HLA-B*38:114 allele expands the known HLA-B allele repertoire.
- Understanding these specific genetic variations is important for immunogenetic studies.
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