Trends in Research on Hypertrophic Cardiomyopathy and Mitochondria From 2003 to 2023: A Bibliometric Analysis

Mitochondria have emerged as a significant and promising area of research in hypertrophic cardiomyopathy (HCM). However, there is a notable scarcity of bibliometric studies in this field. Our aim is to conduct a bibliometric analysis of mitochondrial research in HCM, delineating research hotspots and trends to aid in understanding the focal points and evolving trajectories of both basic and clinical research.

Articles and reviews related to mitochondrial research in hypertrophic cardiomyopathy (HCM) from 2003 to 2023 were filtered from the Web of Science database. CiteSpace software was utilized to generate knowledge maps including keyword analysis, authorship networks, countries of origin, and journal distributions.

A total of 285 relevant articles on HCM and mitochondria were included, with publication output steadily increasing over the years. These publications originated from 47 countries and regions, with the United States and China contributing the most publications. Primary research institutions included UDICE-French Research Universities, Centro de Investigacion Biomedica en Red, and Institut National de la Sante et de la Recherche Medicale (Inserm). J BIOL CHEM and P NATL ACAD SCI USA emerged as prominent journals with substantial research output and authority. We identified 520 authors, with Rachid Boutoual and Scot C Leary having the highest publication outputs, while BJ Maron and D Ghezzi were cited most frequently. Through hotspot analysis, we identified frequently occurring keywords such as Hypertrophic cardiomyopathy, Oxidative stress, Heart failure, Lactic acidosis, Mutations, Disease, Dilated cardiomyopathy, Cardiomyopathy, Deficiency, and Cardiac hypertrophy. Mitochondrial diseases associated with HCM, including Leigh syndrome, Barth syndrome (BTHS), heart failure, arrhythmias, and cardiovascular diseases, represent current and evolving research areas.

Through bibliometric methods, we have elucidated the research hotspots and trends concerning hypertrophic cardiomyopathy (HCM) and mitochondria. The investigation of mitochondria, particularly in the context of cardiovascular medicine and HCM, demonstrates an unstoppable momentum. Research on mitochondria in HCM predominantly focuses on mechanisms, cardiovascular diseases, and therapeutic approaches, which will serve as pivotal areas for future exploration.