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Related Experiment Video

Updated: May 24, 2025

Designing a Bio-responsive Robot from DNA Origami

Designing a Bio-responsive Robot from DNA Origami

Published on: July 8, 2013

DNA/RNA Origami Based on Different Scaffolds and Their Biomedical Applications.

Jing Fan^1,2, Changping Yang^1,2, Hanyin Zhu^2,3

¹School of Materials Science and Engineering, Henan Institute of Advanced Technology, Zhengzhou University, Zhengzhou 450001, China.

ACS Biomaterials Science & Engineering

|March 6, 2025

Summary

Nucleic acid nanostructures, like DNA origami, offer programmable biomaterials for advanced biomedical uses. This review covers recent DNA/RNA origami designs for applications in drug delivery, gene regulation, and diagnostics.

Keywords:

DNA origami RNA origami biomedical applications nucleic acid biomaterials self-assembly

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Last Updated: May 24, 2025

Designing a Bio-responsive Robot from DNA Origami

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Published on: July 8, 2013

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Folding and Characterization of a Bio-responsive Robot from DNA Origami

Published on: December 3, 2015

Area of Science:

Biotechnology
Nanomedicine
Molecular Engineering

Background:

Nucleic acids (DNA and RNA) serve as versatile building blocks for creating complex nanostructures via base pairing.
These self-assembled nucleic acid biomaterials exhibit excellent biocompatibility, spatial control, and design flexibility.
DNA origami, a prominent nanostructure, has garnered significant attention in biomedical research.

Purpose of the Study:

To review recent advancements in DNA/RNA origami design utilizing single-stranded DNA (ssDNA), double-stranded DNA (dsDNA), and single-stranded RNA (ssRNA) scaffolds.
To highlight the diverse biomedical applications of these nucleic acid nanostructures.
To discuss current challenges and future prospects in the field.

Main Methods:

Review of literature on DNA/RNA origami design strategies.
Analysis of applications in drug delivery, gene regulation, immunomodulation, and receptor recognition.
Exploration of different nucleic acid scaffold types (ssDNA, dsDNA, ssRNA).

Main Results:

Summarized latest developments in DNA/RNA origami design and fabrication.
Detailed various biomedical applications, showcasing their potential in targeted therapies and diagnostics.
Identified key trends and innovations in nucleic acid nanotechnology.

Conclusions:

DNA/RNA origami represents a powerful platform for developing advanced biomedical tools.
Continued research promises to expand the utility of these nanostructures in medicine.
Overcoming current challenges will unlock new opportunities for nucleic acid-based therapies and diagnostics.