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La(OTf)3-Catalyzed Benzannulation of 2-Arylidene-1H-indene-1,3(2H)-diones with Enamino Esters: Direct Access to
Xuequan Wang1, Dan Yue1, Changhui Yang1
1Key Laboratory of Natural Pharmaceutical and Chemical Biology of Yunnan Province, School of Chemistry and Resources Engineering, Honghe University, Mengzi, Yunnan 661100, P. R. China.
Abstract:
An attractive method for the preparation of functional fluorenone derivatives has been developed via La(OTf)3-catalyzed benzannulation of 2-arylidene-1H-indene-1,3(2H)-diones with enamino esters. The reaction involves Michael addition, intramolecular cyclization, dehydration, and aromatization in a one-step process and affords a wide range of functional fluorenone derivatives in moderate to good yields. Moreover, this protocol provides several advantages, including broad substrate scope, readily available materials, high atom economy, and applicability for large-scale synthesis.
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