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Updated: May 23, 2025

09:56
Toxoplasma gondii Cyst Wall Formation in Activated Bone Marrow-derived Macrophages and Bradyzoite Conditions
Published on: August 12, 2010
16.1K
Finding the brakes on the Toxoplasma life cycle
Alice L Herneisen1, Sebastian Lourido1
1Whitehead Institute for Biomedical Research, Cambridge, MA, USA; Massachusetts Institute of Technology, Cambridge, MA, USA.
Trends in Parasitology
|March 7, 2025
Abstract
None:
Toxoplasma gondii motility is an all-or-nothing response. Claywell et al. identify negative-feedback loops in cyclic-nucleotide signaling that allow parasites to turn off motility and commit to intracellular replication. Feedback mechanisms and bistability are useful frameworks for describing, modeling, and testing T. gondii motility signaling pathways.
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