Related Experiment Video
Updated: May 23, 2025
04:16
Individualized Reconstitution of Human Milk Microbiota: A Feasible Approach in Real-World Settings
Published on: February 7, 2025
385
Rumen microbiome associates with postpartum ketosis development in dairy cows: a prospective nested case-control
Fanlin Kong1, Shuo Wang1, Yijia Zhang2
1State Key Laboratory of Animal Nutrition and Feeding, Department of Animal Nutrition and Feed Science, College of Animal Science and Technology, China Agricultural University, Beijing, 100193, China.
Microbiome
|March 8, 2025
Summary
Postpartum ketosis in dairy cows is linked to rumen microbiome disruption and lower propionate levels, impacting energy metabolism. Restoring rumen function and increasing propionate may help manage ketosis.
Area of Science:
- Rumen microbiome research
- Dairy cow health
- Metabolic disease in livestock
Background:
- Postpartum diseases affect one-third of dairy cows, with ketosis disrupting energy metabolism.
- The rumen microbiome's role in ketosis etiology via volatile fatty acids is unclear.
- Rumen environmental dynamics in ketosis cows require elucidation.
Purpose of the Study:
- To investigate rumen microbiome changes during parturition in ketosis cows.
- To explore the association between the rumen microbiome and host energy metabolism.
- To understand the impact of ketosis on rumen microbial composition and function.
Main Methods:
- Multi-omics analysis of 810 rumen content and 789 serum samples.
- Comparison between 61 ketosis cows and 84 healthy cows.
- Sampling at day -21 and 21 relative to calving day.
Main Results:
- Ketosis cows showed dramatic, slow-to-restore rumen bacterial composition changes post-calving.
- Lower propionate levels in ketosis cows correlated with higher serum β-hydroxybutyrate (BHBA).
- Rumen microbiome (Prevotella, UBA1066) and diversity indices influenced serum BHBA and glucose via amino acids and propionate.
Conclusions:
- Rumen disruption post-calving is evident in ketosis cows.
- Insufficient glycogenic substrates like propionate may contribute to ketosis.
- Findings support future rumen microbiome research for improved postpartum cow management.
Related Concept Videos
01:23Anatomy of the Intestines
71.2K
Although digestion of proteins, carbohydrates, and lipids may begin in the stomach, it is completed in the intestine. The absorption of nutrients, water, and electrolytes from food and drink also occurs in the intestine. The intestines can be divided into two structurally distinct organs—the small and large intestines.
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
71.2K
01:50What is Monogastric Digestion?
70.4K
The human body contains a monogastric digestive system. In a monogastric digestive system, the stomach only contains one chamber in which it digests food. Several other animal species also have monogastric digestive systems, including pigs, horses, dogs, and birds. This chapter, however, focuses on the human digestive system.
70.4K