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Updated: May 23, 2025

Polysome Fractionation and Analysis of Mammalian Translatomes on a Genome-wide Scale
Published on: May 17, 2014
Post-Transcriptional Regulation of Gene Expression and the Intricate Life of Eukaryotic mRNAs
Carly L Lancaster1,2,3, Kenneth H Moberg2, Anita H Corbett1
1Department of Biology, Emory College of Arts and Sciences, Atlanta, Georgia, USA.
Abstract:
In recent years, there has been a growing appreciation for how regulatory events that occur either co- or post-transcriptionally contribute to the control of gene expression. Messenger RNAs (mRNAs) are extensively regulated throughout their metabolism in a precise spatiotemporal manner that requires sophisticated molecular mechanisms for cell-type-specific gene expression, which dictates cell function. Moreover, dysfunction at any of these steps can result in a variety of human diseases, including cancers, muscular atrophies, and neurological diseases. This review summarizes the steps of the central dogma of molecular biology, focusing on the post-transcriptional regulation of gene expression.
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