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[Deciphering the links between hepatic viruses and interferons: molecular interactions and therapeutic implications]
Cassandre Authier1, Claudie Eber2, Roxanne Fouillé1
1CIRI, Centre International de recherche en infectiologie, Univ Lyon, Inserm, U1111, Université Claude-Bernard Lyon 1, CNRS, UMR5308, ENS de Lyon, F-69007, Lyon, France.
Virologie (Montrouge, France)
|March 10, 2025
Summary
Interferons (IFNs) are crucial for innate immunity and treat viral infections. This review explores how hepatic viruses interact with the IFN pathway, impacting treatment strategies.
Area of Science:
- Immunology
- Virology
- Hepatology
Background:
- Interferons (IFNs) are cytokines vital for innate immunity, exhibiting antiviral, antiproliferative, and immunomodulatory functions.
- IFNs are clinically applied to treat lymphomas, multiple sclerosis, and chronic viral infections like hepatitis B, C, D, and E.
- Chronic infections with HBV, HCV, and HDV are primary causes of liver cancer, while HEV can cause fulminant hepatitis.
Purpose of the Study:
- To review current knowledge on hepatic virus interactions with the interferon (IFN) pathway.
- To elucidate virus-dependent molecular mechanisms governing IFN induction and antiviral responses.
Main Methods:
- Literature review of existing studies on interferons and hepatic viruses.
- Analysis of molecular mechanisms underlying IFN induction and antiviral effects in viral hepatitis.
Main Results:
- IFNs are essential for treating viral hepatitis despite side effects and limited efficacy.
- Understanding virus-IFN pathway interactions is key to improving therapeutic outcomes.
- Hepatic viruses employ diverse strategies to evade or manipulate the IFN response.
Conclusions:
- IFN pathway modulation is critical for managing viral hepatitis and preventing hepatocellular carcinoma.
- Further research into IFN-viral interactions can lead to enhanced therapeutic strategies for liver diseases.
- Targeting specific molecular mechanisms within the IFN pathway offers potential for novel antiviral therapies.
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