Changes in the biochemical composition of semen following danazol plus testosterone enanthate administration to the...

Changes in the biochemical composition of semen, which reflect the accessory sex organ functions, following danazol (100 mg/day; orally) plus testosterone enanthate (50 mg/month; i.m.) administration have been investigated in langur monkey. The levels of acid phosphatase, lactic dehydrogenase and glycerylphosphorylcholine in the semen decreased significantly; whereas fructose, citric acid, magnesium and semen volume did not show any significant changes. A gradual decrease in the motility and count of spermatozoa was observed. At 60 days of treatment all animals became azoospermic. No drug related hematological changes were observed. The combination therapy impaired the epididymal and prostatic functions along with suppression of spermatogenesis.