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Multiple Myeloma Complicated With Bronchiolitis Obliterans Syndrome After Allogeneic Haematopoietic Stem Cell

Shih-Wei Huang1, Ko-Wei Chang1,2, Wei-Hsun Chen3

  • 1Department of Thoracic Medicine Chang Gung Memorial Hospital Taoyuan Taiwan.

Respirology Case Reports
|March 11, 2025
PubMed

Allogeneic haematopoietic stem cell transplantation (allo-HSCT) is an effective treatment for multiple myeloma; however, the development of chronic graft-versus-host disease remains a significant challenge. Bronchiolitis obliterans syndrome (BOS) is one of the complications. Even with available medications for treatment, the prognosis of BOS remains poor. We present a 32-year-old female with multiple myeloma experienced BOS 6 months after allo-HSCT. Even with medical treatment, her clinical condition and pulmonary function was deteriorating. Based on the indication of a BODE (Body-mass index, Obstruction, Dyspnoea and Exercise) index of 7, she underwent bilateral lung transplantation 33 months after allo-HSCT. Three months post-operation, there was a significant improvement in pulmonary function. After approximately 5 years of follow-up, her lung function remains stable, and she is able to work and live a normal life. Lung transplantation may be an effective therapeutic strategy for BOS developed after allo-HSCT.

Keywords:
allogeneic haematopoietic stem cell transplantationbronchiolitis obliterans syndromelung transplantationmultiple myeloma

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