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[Gaillardia allergy].

B M Hausen

    Dermatosen in Beruf Und Umwelt. Occupation and Environment
    |January 1, 1985
    PubMed
    Summary
    This summary is machine-generated.

    Allergic contact dermatitis was caused by handling Gaillardia flowers. Spathulin, a sesquiterpene lactone, was identified as the primary allergen, with cross-reactions to related compounds.

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    Area of Science:

    • Dermatology
    • Allergology
    • Plant Chemistry

    Background:

    • Allergic contact dermatitis (ACD) is a common skin condition.
    • Plant-derived allergens are frequent causes of ACD.
    • Gaillardia species are known to contain sesquiterpene lactones, potential allergens.

    Observation:

    • A 37-year-old savings-bank employee presented with facial and hand dermatitis.
    • Symptoms worsened after applying a body lotion containing Arnica extracts.
    • Non-occupational handling of Gaillardia cultivars was identified as the exposure source.

    Findings:

    • Epicutaneous testing identified spathulin, a Gaillardia sesquiterpene lactone, as the causative agent.
    • Cross-reactivity was observed with other sesquiterpene lactones including telekin, alantolactone, parthenolide, isoalantolactone, and carabrone.

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  • Arnica extracts in a body lotion exacerbated the dermatitis, suggesting potential cross-reactivity or additive effects.

    • Implications:

    • Highlights Gaillardia cultivars as a source of contact allergens.
    • Identifies spathulin as a specific sensitizer in Gaillardia.
    • Warns about potential cross-reactivity within the sesquiterpene lactone family.
    • Suggests caution with topical products containing Arnica or related plant extracts in susceptible individuals.