Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Comparative Epidemiology of Craniofacial Injuries Across 4 Hockey Variants: A NEISS-Based Analysis.

The Journal of craniofacial surgery·2026
Same author

Impact of alcohol cessation on hepatic metabolic signaling during cancer cachexia.

Biochemical and biophysical research communications·2026
Same author

The Most Influential Publications in Genioplasty: A Bibliometric Review.

The Journal of craniofacial surgery·2026
Same author

Benchmarking Large Language Models Against Web of Science: A Comparative Bibliometric Analysis on Panniculectomy.

Annals of plastic surgery·2026
Same author

Motivational Subdomains in Neurodevelopmental Disorders: A Heuristic Circuit Framework for Translational Validation.

Biological psychiatry. Cognitive neuroscience and neuroimaging·2026
Same author

Response of male and female mice to chronic alcohol use before and during cancer.

Alcohol (Fayetteville, N.Y.)·2026

Related Experiment Video

Updated: May 23, 2025

Construction of Vapor Chambers Used to Expose Mice to Alcohol During the Equivalent of all Three Trimesters of Human Development
15:27

Construction of Vapor Chambers Used to Expose Mice to Alcohol During the Equivalent of all Three Trimesters of Human Development

Published on: July 13, 2014

14.6K

Auditory Deficits in a Mouse Model of First-Trimester Prenatal Alcohol Exposure.

Mark Jessup1, Abigail L Tice2,3, Addison McNeill2,3

  • 1Department of Biomedical Sciences, Program in Neuroscience, Florida State University College of Medicine, Tallahassee, Florida, USA.

Developmental Neuroscience
|March 11, 2025
PubMed
Summary

Prenatal alcohol exposure (PAE) in mice during early gestation impacts auditory processing, causing smaller auditory brainstem responses and deficits in auditory gating. Hearing sensitivity remained intact, but specific neural circuit functions were altered.

Keywords:
Auditory brainstem responsesEarly gestational substance useNeural developmentPrenatal alcohol exposureSensory processing

More Related Videos

The Use of Trace Eyeblink Classical Conditioning to Assess Hippocampal Dysfunction in a Rat Model of Fetal Alcohol Spectrum Disorders
19:57

The Use of Trace Eyeblink Classical Conditioning to Assess Hippocampal Dysfunction in a Rat Model of Fetal Alcohol Spectrum Disorders

Published on: August 5, 2017

8.3K
Moderate Prenatal Alcohol Exposure and Quantification of Social Behavior in Adult Rats
11:01

Moderate Prenatal Alcohol Exposure and Quantification of Social Behavior in Adult Rats

Published on: December 14, 2014

9.6K

Related Experiment Videos

Last Updated: May 23, 2025

Construction of Vapor Chambers Used to Expose Mice to Alcohol During the Equivalent of all Three Trimesters of Human Development
15:27

Construction of Vapor Chambers Used to Expose Mice to Alcohol During the Equivalent of all Three Trimesters of Human Development

Published on: July 13, 2014

14.6K
The Use of Trace Eyeblink Classical Conditioning to Assess Hippocampal Dysfunction in a Rat Model of Fetal Alcohol Spectrum Disorders
19:57

The Use of Trace Eyeblink Classical Conditioning to Assess Hippocampal Dysfunction in a Rat Model of Fetal Alcohol Spectrum Disorders

Published on: August 5, 2017

8.3K
Moderate Prenatal Alcohol Exposure and Quantification of Social Behavior in Adult Rats
11:01

Moderate Prenatal Alcohol Exposure and Quantification of Social Behavior in Adult Rats

Published on: December 14, 2014

9.6K

Area of Science:

  • Neuroscience
  • Developmental Biology
  • Auditory Science

Background:

  • Prenatal alcohol exposure (PAE) is linked to neurological deficits and auditory dysfunction.
  • The precise effects of PAE on auditory development are complex and depend on exposure timing and patterns.

Purpose of the Study:

  • To investigate the effects of early gestational alcohol exposure on auditory function in a mouse model.
  • To characterize specific alterations in auditory processing following PAE during the first trimester equivalent.

Main Methods:

  • Developed a mouse model of PAE during the first half of gestation.
  • Assessed auditory function using auditory brainstem responses (ABRs) and acoustic startle tests.
  • Evaluated general health, growth, and anxiety-related behaviors.

Main Results:

  • PAE did not affect overall growth or induce anxiety-like behaviors.
  • Offspring showed smaller ABRs and reduced peak reproducibility, indicating weakened neural synchronization.
  • Deficits in auditory gating (prepulse inhibition) were observed early and persisted, suggesting impaired sound level differentiation.

Conclusions:

  • Early gestational alcohol exposure leads to specific, rather than global, auditory processing deficits.
  • While overall hearing sensitivity is preserved, neural processing within auditory circuits is significantly altered by PAE.