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Related Concept Videos

Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

378
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
378
Glaucoma: Overview01:25

Glaucoma: Overview

488
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
488
Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

420
Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
420

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Related Experiment Video

Updated: May 22, 2025

Glaucoma-inducing Procedure in an In Vivo Rat Model and Whole-mount Retina Preparation
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Pattern of Long-Term Intraocular Pressure Variation Following Gonioscopy-Assisted Transluminal Trabeculotomy:

Bruno M Faria1,2,3, Diego T Dias4,5, Mariana A O Reis6

  • 1Marco Rey Ophthalmology Institute.

Journal of Glaucoma
|March 12, 2025
PubMed
Summary

Gonioscopy-assisted transluminal trabeculotomy (GATT) and phacogatt procedures effectively lowered intraocular pressure (IOP) in open-angle glaucoma patients. Both treatments demonstrated stable IOP patterns over 24 months, offering viable options for managing uncontrolled glaucoma.

Keywords:
gonioscopy-assisted transluminal trabeculotomylong term intraocular pressure variationminimally invasive glaucoma surgery

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Area of Science:

  • Ophthalmology
  • Glaucoma Surgery
  • Intraocular Pressure Management

Background:

  • Open-angle glaucoma requires effective long-term intraocular pressure (IOP) control.
  • Medically uncontrolled glaucoma presents significant challenges for sustained IOP management.

Purpose of the Study:

  • To evaluate the long-term impact of gonioscopy-assisted transluminal trabeculotomy (GATT) on intraocular pressure (IOP) variation.
  • To compare standalone GATT with combined phacoemulsification and GATT (PHACOGATT) in managing open-angle glaucoma.

Main Methods:

  • A retrospective study of 169 patients with clinically uncontrolled open-angle glaucoma.
  • Patients underwent either standalone GATT or PHACOGATT, with follow-up of at least 12 months.
  • Key metrics included long-term mean IOP, IOP peaks, IOP fluctuation, and coefficient of variation.

Main Results:

  • Both GATT and PHACOGATT resulted in low mean IOPs and stable IOP patterns over 24 months.
  • The PHACOGATT group showed lower mean long-term IOP and IOP peaks compared to the GATT group.
  • A low percentage of patients (6.5%) exhibited sustained clinically significant positive IOP variation.

Conclusions:

  • GATT and PHACOGATT are effective in achieving and maintaining low intraocular pressure in patients with open-angle glaucoma.
  • These procedures offer stable IOP profiles, supporting their use in managing medically uncontrolled glaucoma.
  • The findings provide further evidence for GATT and PHACOGATT as valuable surgical options for glaucoma patients.