Adrenocortical carcinoma: a practical guide for clinicians.

Area of Science:

• Endocrinology
• Oncology

Background:

• Adrenocortical carcinoma (ACC) is a rare and aggressive endocrine malignancy.
• Patient management is complicated by hormonal excess, limited evidence, and few specialized centers.

Purpose of the Study:

• To address critical clinical management questions in adult adrenocortical carcinoma.
• To provide expert perspectives based on extensive clinical experience and published data.

Main Methods:

• A review of 25 frequently asked questions regarding adrenocortical carcinoma management.
• Synthesis of published evidence and over 60 years of collective clinical experience from two major European centers.

Main Results:

• The review consolidates expert answers to complex clinical scenarios in ACC.
• It highlights the challenges and nuances in diagnosing and treating this rare cancer.

Conclusions:

• This expert-driven review offers practical guidance for managing adrenocortical carcinoma.
• It aims to improve patient care by addressing knowledge gaps and sharing clinical insights.