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Updated: May 22, 2025
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Evaluation of Tumor-infiltrating Leukocyte Subsets in a Subcutaneous Tumor Model
Published on: April 13, 2015
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Surgical Considerations in Tumor-Infiltrating Lymphocyte Therapy: Challenges and Opportunities
Amanda Kirane1, David Lee1, Charlotte Ariyan2
1Stanford University, Department of Surgery, 1201 Welch Road, Stanford, CA 94304.
Transplantation and Cellular Therapy
|March 15, 2025
Summary
Adoptive T cell therapy (ACT) using tumor-infiltrating lymphocytes (TILs) offers a personalized cancer treatment. Surgeons play a key role in harvesting TILs for improved quality and effectiveness in cancer immunotherapy.
Area of Science:
- Oncology
- Immunotherapy
- Surgical Oncology
Background:
- Adoptive T cell therapy (ACT) with tumor-infiltrating lymphocytes (TILs) is a personalized immunotherapy.
- Recent advancements show TIL therapy's superiority over immune checkpoint blockade, even post-anti-PD-1 failure in metastatic melanoma.
- Expedited manufacturing and FDA approval of lifileucel are driving TIL therapy adoption.
Purpose of the Study:
- To highlight the critical surgical aspects of TIL harvesting for ACT.
- To emphasize the surgeon's role in optimizing TIL quality, safety, and efficacy.
- To foster collaboration for advancing TIL therapy in oncology.
Main Methods:
- Commentary on surgical techniques for TIL harvesting.
- Discussion of factors influencing TIL quality and yield.
- Review of safety considerations in TIL therapy procedures.
Main Results:
- Surgical technique directly impacts the quality and therapeutic potential of TILs.
- Optimal harvesting ensures patient safety and enhances treatment effectiveness.
- Collaboration between surgeons and immunologists is crucial for successful TIL therapy.
Conclusions:
- Surgeons are integral to the success of TIL-based ACT.
- Addressing surgical considerations will advance TIL therapy for various cancers.
- Enhanced surgical protocols can improve outcomes for patients with limited treatment options.
