Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

An update on the network theory of epilepsy.

Frontiers in network physiology·2026

Same author

Quantitative electroencephalographic measures during postmalarial epileptogenesis.

Epilepsia·2026

Same author

Language mapped to a high-resolution brain atlas for surgical evaluation of epilepsy patients.

Epilepsia·2026

Same author

Responsive neurostimulation targeting the primary motor cortex for treatment of drug-resistant epilepsy.

Seizure·2026

Same author

Dose escalation in pentylenetetrazol kindling detects differences in chronic seizure susceptibility.

Epilepsy research·2026

Same author

Spatial and spectral structure of local functional connectivity of the background intracranial EEG in patients with focal epilepsy.

Frontiers in network physiology·2026

Same journal

Serum vitamin D level and its association with vertigo frequency and severity in Meniere disease.

Scientific reports·2026

Same journal

PFA-Net: a physics-informed feature enhancement and attention network for interpretable bearing fault diagnosis under strong noise.

Scientific reports·2026

Same journal

Circulating inflammatory, redox, and apoptosis-related alterations in drug-naive idiopathic pulmonary fibrosis: an exploratory case-control study.

Scientific reports·2026

Same journal

A baseline-oriented dynamic aggregation approach for demand-side heterogeneous controllable resources.

Scientific reports·2026

Same journal

Temporal precision and accuracy in schizophrenia: an exploratory study.

Scientific reports·2026

Same journal

Prefrontal EEG spectral and nonlinear signatures of subthreshold depression during resting state and affectively valenced picture/video viewing: a participant-level analysis.

Scientific reports·2026

See all related articles

Search research articles

Related Experiment Video

Updated: May 21, 2025

Network Analysis of the Default Mode Network Using Functional Connectivity MRI in Temporal Lobe Epilepsy

Network Analysis of the Default Mode Network Using Functional Connectivity MRI in Temporal Lobe Epilepsy

Published on: August 5, 2014

Identifying the epileptic network by linking interictal functional and structural connectivity.

Ujwal Boddeti^1,2, Pue Farooque³, Hari McGrath³

¹Surgical Neurology Branch, NINDS, National Institutes of Health, Bethesda, MD, 20892, USA.

Scientific Reports

|March 18, 2025

Summary

This summary is machine-generated.

Epilepsy is a network disorder. This study found that functional seizure networks persist between seizures, suggesting that disrupting these networks may improve surgical outcomes for epilepsy patients.

Keywords:

Diffusion tensor imaging Epilepsy Functional connectivity Interictal connectivity Mesial temporal lobe epilepsy Seizure networks

More Related Videos

A Multimodal Imaging- and Stimulation-based Method of Evaluating Connectivity-related Brain Excitability in Patients with Epilepsy

A Multimodal Imaging- and Stimulation-based Method of Evaluating Connectivity-related Brain Excitability in Patients with Epilepsy

Published on: November 13, 2016

Network Analysis of Foramen Ovale Electrode Recordings in Drug-resistant Temporal Lobe Epilepsy Patients

Network Analysis of Foramen Ovale Electrode Recordings in Drug-resistant Temporal Lobe Epilepsy Patients

Published on: December 18, 2016

Related Experiment Videos

Last Updated: May 21, 2025

Network Analysis of the Default Mode Network Using Functional Connectivity MRI in Temporal Lobe Epilepsy

Network Analysis of the Default Mode Network Using Functional Connectivity MRI in Temporal Lobe Epilepsy

Published on: August 5, 2014

A Multimodal Imaging- and Stimulation-based Method of Evaluating Connectivity-related Brain Excitability in Patients with Epilepsy

A Multimodal Imaging- and Stimulation-based Method of Evaluating Connectivity-related Brain Excitability in Patients with Epilepsy

Published on: November 13, 2016

Network Analysis of Foramen Ovale Electrode Recordings in Drug-resistant Temporal Lobe Epilepsy Patients

Network Analysis of Foramen Ovale Electrode Recordings in Drug-resistant Temporal Lobe Epilepsy Patients

Published on: December 18, 2016

Area of Science:

Neuroscience
Epileptology
Network Medicine

Background:

Epilepsy is increasingly recognized as a complex network disorder.
The persistence of these seizure networks between epileptic seizures (interictally) remains unclear.

Purpose of the Study:

To determine if functional seizure networks exist during interictal periods.
To investigate the structural basis of these interictal networks.
To correlate network connectivity with surgical outcomes in epilepsy.

Main Methods:

Analysis of functional and structural connectivity using intracranial electrodes in four patients with mesial temporal lobe epilepsy undergoing surgery.
Comparison of connectivity in seizure onset, early spread, and control regions during interictal epochs.

Main Results:

Cortical regions involved in seizure spread exhibited higher functional and white matter connectivity during interictal periods.
The patient with the best post-operative seizure outcome demonstrated the highest functional connectivity across seizure contacts.

Conclusions:

Functional connectivity data supports the existence of interictal seizure networks that mirror underlying structural connectivity.
Targeting and ablating highly connected seizure regions may be crucial for achieving seizure freedom after epilepsy surgery.