An Atypical Presentation of Sweet's Syndrome in a Patient With Neutropenia: A Case Report

Sweet syndrome (SS), or acute febrile neutrophilic dermatosis, is a non-infectious inflammatory skin reaction characterized by the abrupt onset of tender, erythematous skin lesions commonly appearing on the head, neck, trunk, and upper extremities. The condition remains rare and multifaceted, often posing a diagnostic challenge. There is a broader spectrum of SS than previously recognized, encompassing a variety of overlapping features, clinical and histological variants, and associated diseases. We report an atypical presentation of Sweet Syndrome in a 54-year-old female with neutropenia and myelodysplastic syndrome to enhance awareness and management of this rare condition among hospitalists. It demonstrates how SS can develop in the context of chemotherapy-induced neutropenia, thereby highlighting the importance of recognizing this case presentation in relevant clinical scenarios.