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06:57
Adjuvant Activity of Mycobacterium paratuberculosis in Enhancing the Immunogenicity of Autoantigens During Experimental Autoimmune Encephalomyelitis
Published on: May 12, 2023
Immunotherapy-Induced Glutamic Acid Decarboxylase 65 Cerebellitis
Alysse Jensen1, Hardik Thakkar1, Scott Kramer1
1Internal Medicine, Moffitt Cancer Center, Tampa, USA.
Cureus
|June 22, 2026
Summary
Immune checkpoint inhibitors (ICIs) can cause rare neurotoxicities like cerebellitis. Early detection and treatment of anti-GAD 65 antibody-related ICI cerebellitis are crucial for better patient outcomes.
Area of Science:
- Oncology
- Neuroimmunology
- Immunotherapy
Background:
- Immune checkpoint inhibitors (ICIs) are vital for advanced cancer treatment.
- ICIs can cause immune-related adverse events (irAEs) due to their mechanism of action.
- Cerebellitis is a rare but severe ICI-induced neurotoxicity.
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