The hippocampus-IPL connectivity links to ADHD traits through sensory processing sensitivity
Liyu Zhou1, Ting Xu1,2, Tingyong Feng1,2
1Faculty of Psychology, Southwest University, No. 2, Tiansheng Road, Beibei, Chongqing 400715, China.
Cerebral Cortex (New York, N.Y. : 1991)
|March 19, 2025
Summary
Individuals with high sensory processing sensitivity show increased attention deficit traits. This is linked to stronger brain connectivity between the hippocampus and the attention network, suggesting a neural basis for sensory overload and distractibility.
Area of Science:
- Neuroscience
- Psychology
Background:
- High sensory processing sensitivity is linked to sensory overload and attention difficulties, resembling attention-deficit/hyperactivity disorder (ADHD).
- Neural underpinnings of the relationship between sensory processing sensitivity and attention deficit remain unclear.
Purpose of the Study:
- To investigate the association between sensory processing sensitivity and attention deficit traits.
- To identify neural substrates, specifically functional connectivity, related to sensory processing sensitivity and attention deficit.
Main Methods:
- Quantified sensory processing sensitivity (Highly Sensitive Person Scale) and attention deficit (Adult Attention-deficit/Hyperactivity Disorder Self-Report Scale).
- Utilized resting-state functional Magnetic Resonance Imaging (fMRI) to analyze neural connectivity.
- Performed mediation analysis to explore the role of hippocampus-Inferior Parietal Lobule (IPL) connectivity.
Main Results:
- A significant positive correlation was found between sensory processing sensitivity and attention deficit traits.
- Sensory processing sensitivity scores positively correlated with functional connectivity between the rostral hippocampus and the inferior parietal lobule (IPL).
- Hippocampus-IPL connectivity mediated the relationship between sensory processing sensitivity and attention deficit.
Conclusions:
- Enhanced functional coupling between the hippocampus and attention network regions may underlie heightened sensitivity to stimuli.
- This enhanced connectivity might contribute to increased distractibility and attention deficit symptoms.
- The findings provide insights into the neural mechanisms linking sensory processing sensitivity and attention deficit.
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