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Updated: May 21, 2025

Synthesis of a Borylated Ibuprofen Derivative Through Suzuki Cross-Coupling and Alkene Boracarboxylation Reactions
Published on: November 30, 2022
Cuprate ion-pair catalyzed conjugate borylation of vinyl sulfones in a biphasic system
Siyu Jiang1, Yicen Ge1, Ai Zhang1
1College of Materials, Chemistry and Chemical Engineering, Chengdu University of Technology, Chengdu, Sichuan 610059, China. geyicen@cdut.edu.cn.
Abstract:
Herein we report the conjugate borylation of vinyl sulfones mediated by ion pairing, which enables the efficient synthesis of β-sulfonyl alcohols bearing diverse functionalities in 13-98% yields. Further mechanistic investigations suggest the formation of anionic boryl-copper intermediates that kinetically accelerate reactant transfer across phases and provide enhanced boryl nucleophilicity.
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