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Benzamide-Directed Hydroarylative Cross-Couplings Using Minimally Activated Alkenes: Enantioselective Synthesis of
Timothy P Aldhous1,2, Raymond Chung1, Abbas Hassan1,3
1Department of Chemistry, University of Liverpool, Crown Street, Liverpool, L69 7ZD, UK.
Abstract:
Ir-systems modified with ferrocene-based homochiral diphosphonite ligands, prepared from functionalized SPINOL derivatives, promote benzamide-directed hydroarylative cross-couplings involving minimally activated alkenes. The processes are highly branched selective and enantioselective. Accordingly, tertiary benzylic stereocenters are generated under byproduct-free conditions. This contrast with conventional cross-coupling approaches, which are less step and atom economical. Preliminary results show that the process extends to the formation of quaternary benzylic stereocenters.
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