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Updated: May 21, 2025

Simultaneous Imaging and Flow-Cytometry-based Detection of Multiple Fluorescent Senescence Markers in Therapy-Induced Senescent Cancer Cells
Published on: July 12, 2022
Dual-target-activated dual-color molecular probe for imaging analysis of cellular senescence
Linlin Wang1, Donghui Hong1, Jili Li1
1Molecular Science and Biomedicine Laboratory (MBL), State Key Laboratory of Chemo and Biosensing, College of Chemistry and Chemical Engineering, Aptamer Engineering Center of Hunan Province, Hunan University, Changsha, Hunan 410082, China. lijili@hnu.edu.cn.
Abstract:
A dual target-activated dual-color fluorescent senoprobe is developed. Unlike traditional probes that rely on tandem linkage and sequential activation, this design adheres to a principle of independent response and independent reporting, enabling in situ and concurrent imaging analysis of two different biomarkers during cellular senescence.
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