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Melatonin: The potential avenues in dentistry
Dr Sanidhya S1, Deepa Kamath1, Aradhya Sinha1
1Department of Periodontology, Manipal Academy of Higher Education, Manipal, Karnataka, 575001, India.
F1000Research
|March 24, 2025
Summary
Melatonin offers promising dental applications due to its antioxidant and anti-inflammatory effects, aiding in periodontal disease treatment and dental implant success. It also serves as a potential alternative for managing dental anxiety.
Area of Science:
- Dentistry
- Pharmacology
- Immunology
Background:
- Periodontal disease involves bacterial plaque and an overactive immune-inflammatory response.
- Current treatments focus on plaque removal and managing tissue damage from reactive oxygen species.
- Melatonin possesses antioxidant, anti-inflammatory, and immunomodulatory properties beneficial for oral health.
Purpose of the Study:
- To summarize the clinical applications of melatonin in dentistry.
- To describe melatonin's mechanism of action in oral conditions.
- To explore future research directions for melatonin in dental treatments.
Main Methods:
- Review of recent studies on melatonin's use in periodontal therapy.
- Analysis of melatonin's effects on bone metabolism and circadian rhythm.
- Examination of melatonin's role in managing dental anxiety.
Main Results:
- Melatonin demonstrates efficacy as an adjunct to mechanical debridement for periodontal disease.
- Systemic administration of melatonin shows benefits post-Non-Surgical Periodontal Therapy.
- Melatonin aids in osseointegration of dental implants and modulates immune responses.
Conclusions:
- Melatonin is a promising therapeutic agent in dentistry for periodontal health and implantology.
- Its antioxidant and anti-inflammatory properties offer advantages over traditional treatments.
- Further research is warranted to fully elucidate melatonin's potential in various dental applications.
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