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Updated: May 20, 2025

An In Ovo Model for Testing Insulin-mimetic Compounds
Published on: April 23, 2018
Antidiabetic protolimonoids from the bark of Entandrophragma angolense
Binh T D Trinh1, Nhung T H Nguyen1, Ngoc T N Ngo1
1Natural Product and Medicinal Chemistry Lab, Faculty of Chemistry, VNUHCM-University of Science, 227 Nguyen Van Cu Street, District 5, Ho Chi Minh City 700000, Viet Nam; Vietnam National University, Ho Chi Minh City 700000, Viet Nam.
Abstract:
Three new protolimonoids, entandrophins A-C (1-3), together with two known compounds, methyl angolensate (4) and stigmas-4-en-3-one (5), were isolated from the bark of Entandrophragma angolense. Their structures were elucidated based on spectroscopic analyses, mainly 1D and 2D NMR spectral data. The compounds were evaluated for their cytotoxicity against HepG2 cells and α-glucosidase inhibitory activity. Compounds 1-4 displayed very weak activity against HepG2 cells but compounds 2 and 3 exhibited significant α-glucosidase inhibition with IC50 values of 57.5 ± 1.5 and 32.5 ± 0.9 μM, respectively.
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