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Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
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Updated: May 20, 2025

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Exploring fluoride's role in diabetes development: A review.

Ruhi Thakur1, Srishti Rana1, Rashi Baltoo1

  • 1School of Biological and Environmental Sciences, Shoolini University, Solan, India.

Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)
|March 25, 2025
PubMed
Summary
This summary is machine-generated.

Excessive fluoride intake may negatively impact glucose metabolism, potentially increasing insulin resistance and diabetes complications. Further research is crucial for understanding fluoride

Keywords:
Blood glucoseDiabetesFluorideHomeostasisInsulin

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Area of Science:

  • Environmental Health
  • Toxicology
  • Endocrinology

Background:

  • Fluoride, an element rarely found free in nature, is the source of the fluoride ion.
  • Excessive fluoride intake can lead to various impairments in living organisms.
  • Understanding fluoride's impact on metabolic health is critical.

Purpose of the Study:

  • To review the relationship between fluoride exposure and glucose metabolism.
  • To assess fluoride's role in insulin resistance and diabetes-related complications.
  • To consider positive, negative, and null findings in existing research.

Main Methods:

  • Analysis of 20 relevant research papers from PubMed, Google Scholar, and ResearchGate up to January 2025.
  • Inclusion of studies using search terms like 'Fluoride,' 'Toxicity,' 'Diabetes,' and 'Insulin resistance.'
  • Categorization of studies into normal organisms (14), diabetic animals (5), and human populations (1).

Main Results:

  • Findings suggest a negative association between fluoride exposure and diabetes.
  • Evidence indicates fluoride's potential to impair glucose homeostasis.
  • Studies show fluoride's role in increasing insulin resistance and affecting blood sugar control.

Conclusions:

  • Comprehending fluoride's contribution to diabetes and its complications is essential.
  • Recommendations for future research are provided to discover effective preventive measures.
  • Further investigation is needed to develop strategies for mitigating fluoride-induced metabolic disturbances.