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Related Concept Videos

Superplasticizers01:30

Superplasticizers

Superplasticizers are advanced admixtures that enhance the workability of concrete by lowering the water content without compromising the strength of the material. These substances are highly effective water reducers, improving concrete flow, making it easier to work with, and enabling concrete to reach inaccessible areas or densely reinforced sections without mechanical vibration. The key components in superplasticizers are either sulfonated melamine or naphthalene formaldehyde condensates,...
Additives and Fillers in Concrete01:29

Additives and Fillers in Concrete

Additives and fillers are integral to enhancing the properties of concrete. Pozzolans and blast-furnace slag are additives or admixtures due to their reactions with calcium hydroxide released during cement hydration. Fillers, which are finely ground and similar in fineness to Portland cement, improve concrete attributes such as workability density, and reduce capillary bleeding or cracking. Some fillers possess hydraulic properties or participate in benign reactions within the cement paste.
The...
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Waterproofing and Anti-Bacterial Admixtures in Concrete

Concrete's susceptibility to water absorption is due to the capillary action within the pores of its hydrated cement paste. This action draws water in, creating the need for waterproofing admixtures to prevent such penetration. The efficacy of these admixtures is contingent upon the water pressure, with variations arising from different conditions such as rain, capillary rise, or hydrostatic pressure in structures intended to hold water.
Waterproofing admixtures render concrete hydrophobic,...

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Updated: Jun 26, 2026

Electrospun Fibrous Scaffolds of Polyglycerol-dodecanedioate for Engineering Neural Tissues From Mouse Embryonic Stem Cells
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Biopolymeric Scaffolds with Melatonin for Tissue Engineering-A Review.

Beata Kaczmarek-Szczepańska1, Sylwia Grabska-Zielińska2

  • 1Laboratory for Functional Polymeric Materials, Faculty of Chemistry, Nicolaus Copernicus University in Torun, Gagarin 7, 87-100 Toruń, Poland.

International Journal of Molecular Sciences
|March 27, 2025
PubMed
Summary

Melatonin enhances biopolymeric scaffolds for tissue engineering, promoting regeneration and healing. Research focuses on overcoming stability challenges and optimizing delivery for diverse regenerative medicine applications.

Keywords:
biopolymersmelatoninscaffoldstissue engineering

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Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Biochemistry

Background:

  • Melatonin is a natural hormone with antioxidant, anti-inflammatory, and regenerative properties.
  • Biopolymeric scaffolds mimic the extracellular matrix to support tissue regeneration.
  • Integrating melatonin into scaffolds enhances their therapeutic potential.

Purpose of the Study:

  • To review the current progress, challenges, and opportunities of using melatonin in tissue engineering.
  • To explore how melatonin-enriched scaffolds can improve cell proliferation, inflammation modulation, and wound healing.
  • To discuss innovative fabrication methods for controlled melatonin delivery.

Main Methods:

  • Literature review of studies on melatonin and tissue engineering scaffolds.
  • Analysis of fabrication techniques like electrospinning, 3D printing, and lyophilization for scaffold creation.
  • Investigation of strategies for combining melatonin with other therapeutic agents.

Main Results:

  • Melatonin incorporation into scaffolds promotes cell proliferation and modulates inflammatory responses.
  • Fabrication methods allow for precise control over scaffold architecture and melatonin release kinetics.
  • Melatonin-enriched scaffolds show promise for applications in wound healing, bone, and nerve regeneration.

Conclusions:

  • Melatonin-enriched biopolymeric scaffolds offer significant potential for advancing regenerative medicine.
  • Overcoming melatonin's stability and release challenges is crucial for clinical translation.
  • Multifunctional scaffolds combining melatonin with other agents present transformative therapeutic opportunities.