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Updated: May 13, 2026
08:48
Bio-energetics Investigation of Candida albicans Using Real-time Extracellular Flux Analysis
Published on: March 19, 2019
Candida auris: A Continuing Threat
Ashish Bhargava1,2, Katherine Klamer1, Mamta Sharma1
1Thomas Mackey Center of Infectious Diseases, Henry Ford Health-St. John Hospital, Detroit, MI 48236, USA.
Microorganisms
|March 27, 2025
Summary
Candida auris, a critical fungal pathogen, exhibits antifungal resistance and environmental persistence, leading to high mortality rates. This review summarizes its current status to guide future research and interventions.
Area of Science:
- Medical Mycology
- Infectious Diseases
- Public Health
Background:
- Candida auris is a critical-priority fungal pathogen identified by the WHO.
- It demonstrates variable resistance to antifungal medications.
- Genomic analysis reveals multiple clades appearing globally.
Purpose of the Study:
- To review the current understanding of Candida auris.
- To highlight factors contributing to its success.
- To provide guidance for future research and clinical management.
Main Methods:
- Literature review of existing studies on Candida auris.
- Genomic analysis of identified clades.
- Epidemiological data compilation.
Main Results:
- Candida auris exhibits significant antifungal resistance.
- It possesses traits for environmental colonization and persistence.
- Thermotolerance contributes to its survival and spread.
- High mortality rates are associated with C. auris infections, particularly in vulnerable patients.
Conclusions:
- Candida auris poses a significant global health threat due to its resistance and adaptability.
- Understanding its characteristics is crucial for effective control strategies.
- Further research is needed to combat this emerging pathogen.
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