Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

267
Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
267
Regulation of Hematopoietic Stem Cells01:01

Regulation of Hematopoietic Stem Cells

3.1K
All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
3.1K
Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

4.0K
Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
4.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Provider perceptions of an antimicrobial stewardship program in immunocompromised patients at a cancer center.

Antimicrobial stewardship & healthcare epidemiology : ASHE·2026
Same author

Diagnostic Testing in Patients with a Clinical Diagnosis of Pneumonia.

Clinics in chest medicine·2026
Same author

Clostridioides difficile Infection Among Hospitalized Patients With Cancer.

JAMA network open·2026
Same author

No Increased Risk of Infection Following a Protocol Change to Decrease Duration of Perioperative Antibiotic Prophylaxis in Liver Transplantation.

Transplant infectious disease : an official journal of the Transplantation Society·2026
Same author

Clinical outcomes with oral cephalosporins as definitive treatment of Enterobacterales bacteremia from a urinary source based on cefazolin minimum inhibitory concentration.

Antimicrobial agents and chemotherapy·2026
Same author

Fungal diagnostic stewardship in immunocompromised populations: a focus on molds and dimorphic fungi.

Clinical microbiology reviews·2026

Related Experiment Video

Updated: May 20, 2025

Generation of Multivirus-specific T Cells to Prevent/treat Viral Infections after Allogeneic Hematopoietic Stem Cell Transplant
08:52

Generation of Multivirus-specific T Cells to Prevent/treat Viral Infections after Allogeneic Hematopoietic Stem Cell Transplant

Published on: May 27, 2011

17.1K

Polyomaviruses After Allogeneic Hematopoietic Stem Cell Transplantation.

Maria Alejandra Mendoza1, Hannah Imlay1

  • 1Division of Infectious Diseases, Department of Internal Medicine, University of Utah, Salt Lake City, UT 84112, USA.

Viruses
|March 27, 2025
PubMed
Summary

Polyomaviruses (PyVs) cause serious illness in stem cell transplant patients. Current treatments are limited, highlighting the need for better diagnostics and therapies for BK polyomavirus (BKPyV) and JC polyomavirus (JCPyV) infections.

Keywords:
BK virusJC virushematopoietic stem cell transplanthemorrhagic cystitispolyomavirusprogressive multifocal leukoencephalopathy

More Related Videos

Development of an IFN-γ ELISpot Assay to Assess Varicella-Zoster Virus-specific Cell-mediated Immunity Following Umbilical Cord Blood Transplantation
08:04

Development of an IFN-γ ELISpot Assay to Assess Varicella-Zoster Virus-specific Cell-mediated Immunity Following Umbilical Cord Blood Transplantation

Published on: July 9, 2014

15.6K
Expanding Cytotoxic T Lymphocytes from Umbilical Cord Blood that Target Cytomegalovirus, Epstein-Barr Virus, and Adenovirus
11:18

Expanding Cytotoxic T Lymphocytes from Umbilical Cord Blood that Target Cytomegalovirus, Epstein-Barr Virus, and Adenovirus

Published on: May 7, 2012

12.7K

Related Experiment Videos

Last Updated: May 20, 2025

Generation of Multivirus-specific T Cells to Prevent/treat Viral Infections after Allogeneic Hematopoietic Stem Cell Transplant
08:52

Generation of Multivirus-specific T Cells to Prevent/treat Viral Infections after Allogeneic Hematopoietic Stem Cell Transplant

Published on: May 27, 2011

17.1K
Development of an IFN-γ ELISpot Assay to Assess Varicella-Zoster Virus-specific Cell-mediated Immunity Following Umbilical Cord Blood Transplantation
08:04

Development of an IFN-γ ELISpot Assay to Assess Varicella-Zoster Virus-specific Cell-mediated Immunity Following Umbilical Cord Blood Transplantation

Published on: July 9, 2014

15.6K
Expanding Cytotoxic T Lymphocytes from Umbilical Cord Blood that Target Cytomegalovirus, Epstein-Barr Virus, and Adenovirus
11:18

Expanding Cytotoxic T Lymphocytes from Umbilical Cord Blood that Target Cytomegalovirus, Epstein-Barr Virus, and Adenovirus

Published on: May 7, 2012

12.7K

Area of Science:

  • Virology
  • Immunology
  • Oncology

Background:

  • Polyomaviruses (PyVs), including BK polyomavirus (BKPyV) and JC polyomavirus (JCPyV), are significant causes of morbidity in allogeneic hematopoietic stem cell transplant (allo-HSCT) recipients.
  • Viral reactivation under immunosuppression leads to diseases like BKPyV-associated hemorrhagic cystitis (HC) and JCPyV-associated progressive multifocal leukoencephalopathy (PML).

Purpose of the Study:

  • This review synthesizes current knowledge on PyV virology, clinical manifestations, and management challenges in the context of allo-HSCT.
  • It emphasizes the critical need for advancements in diagnostic tools and therapeutic strategies to improve outcomes for this patient population.

Main Methods:

  • Literature review focusing on polyomavirus infections post-allo-HSCT.
  • Analysis of clinical presentations, diagnostic methods, and treatment outcomes.

Main Results:

  • BKPyV commonly causes hemorrhagic cystitis, while JCPyV can lead to progressive multifocal leukoencephalopathy.
  • Diagnosis relies on nucleic acid amplification testing and clinical assessment.
  • Effective antiviral treatments are lacking, with management primarily supportive.

Conclusions:

  • Polyomavirus infections pose a substantial threat to allo-HSCT recipients, necessitating improved diagnostic accuracy and novel therapeutic interventions.
  • Further research is crucial to develop effective treatments and mitigate the morbidity and mortality associated with these viral infections.