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Bioavailability Enhancement: Drug Permeability Enhancement01:27

Bioavailability Enhancement: Drug Permeability Enhancement

After oral administration, poor permeability often limits the rate at which drugs are absorbed through the intestinal epithelium. Enhancing drug permeability is crucial for effective therapy, and several strategies have been developed to overcome this challenge.One effective strategy involves the use of lipid-based formulations. These formulations enhance dissolution and solubility, targeting physiological mechanisms to increase drug absorption. This includes stimulating bile salt secretion,...

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Liposome-Based Interventions in Knee Osteoarthritis.

Evgenia Mitsou1,2, Jacob Klein1

  • 1Department of Molecular Chemistry and Materials Science, Weizmann Institute of Science, Hertzl Street 234, Rehovot, 7610001, Israel.

Small (Weinheim an Der Bergstrasse, Germany)
|March 27, 2025
PubMed
Summary

Liposomes offer a promising intra-articular (IA) treatment for osteoarthritis (OA), improving drug retention and targeting within the knee joint. This review highlights their potential as carriers and lubricants for novel OA therapies.

Keywords:
drug deliveryintra‐articular administrationknee osteoarthritisliposomeslubrication

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Area of Science:

  • Biomedical Engineering
  • Nanotechnology in Medicine
  • Rheumatology

Background:

  • Osteoarthritis (OA) is a prevalent degenerative joint disease causing significant disability and burden, affecting both aging and younger populations.
  • Current systemic OA treatments (oral, intravenous) have adverse effects, increasing interest in intra-articular (IA) therapies.
  • Free IA-injected drugs have short retention times and limited targeting capabilities in the knee joint, necessitating frequent injections.

Purpose of the Study:

  • To review the research on intra-articular liposomal formulations for knee osteoarthritis over the past decade.
  • To investigate the properties of liposomes as pharmaceutical carriers and lubricating agents for OA management.
  • To explore the potential of liposomes in combinatorial approaches for novel OA treatment solutions.

Main Methods:

  • Literature review of scientific research published in the last 10 years.
  • Analysis of studies focusing on intra-articular liposomal formulations for osteoarthritis.
  • Evaluation of liposomal properties including drug delivery, retention, and targeting efficacy.

Main Results:

  • Liposomes demonstrate tunable characteristics making them suitable for intra-articular drug delivery in OA.
  • IA liposomal formulations show potential for improved drug retention and targeted delivery within the knee joint compared to free drugs.
  • Liposomes can function as pharmaceutical carriers and lubricating agents, offering multifaceted benefits for OA management.

Conclusions:

  • Intra-articular liposomal formulations represent a promising strategy for enhancing osteoarthritis treatment efficacy.
  • Liposomes offer advantages in drug retention, targeting, and potential for combinatorial therapies for knee OA.
  • Further research into liposomal applications could lead to innovative and improved therapeutic solutions for osteoarthritis.