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MiceDEGdb: a knowledge base on differentially expressed mouse genes as a model object in biomedical research
O A Podkolodnaya1, I V Chadaeva2, S V Filonov1
1Institute of Cytology and Genetics of the Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia.
Vavilovskii Zhurnal Genetiki I Selektsii
|March 27, 2025
Summary
MiceDEGdb is a new database detailing gene expression changes in mouse models for human diseases. It links mouse gene expression data to human disease studies, aiding biomedical research and drug development.
Area of Science:
- Biomedical Research
- Genomics
- Bioinformatics
Background:
- Mouse models are crucial for understanding human diseases and testing therapeutics.
- Mice are widely used in pharmaceutical research due to their genetic tractability and small size.
Purpose of the Study:
- To introduce MiceDEGdb, a pilot knowledge base of differentially expressed genes (DEGs) in mouse models.
- To curate and annotate gene expression data from mouse models of age-related human diseases.
Main Methods:
- Compiled data from 25 RNA-seq experiments across six mouse strains and eight tissues.
- Annotated mouse DEGs with human homolog expression changes from independent studies.
- Included data on 9,769 unique mouse genes and 318 human genes across 895 diseases.
Main Results:
- The pilot MiceDEGdb contains 21,754 DEGs from mouse models of diseases like hypertension and heart failure.
- It provides 85,092 annotations linking mouse gene expression to human disease homologs.
- Data is sourced from 10 original articles and references 912 scientific publications.
Conclusions:
- MiceDEGdb offers a valuable resource for researchers studying gene expression in disease.
- The database facilitates the translation of mouse model findings to human health.
- It supports geneticists, biologists, and clinicians in personalized medicine approaches.
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