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Pathologic changes associated with induced small intestinal strangulation obstruction and nonstrangulating infarction
American Journal of Veterinary Research
|April 1, 1985
Summary
Ischemic or hemorrhagic strangulation obstruction in horse jejunum caused distinct gross and microscopic changes. Hemorrhagic strangulation obstruction led to more apparent gross changes, particularly in the mucosal layer.
Area of Science:
- Veterinary Pathology
- Gastrointestinal Surgery
- Equine Medicine
Background:
- Intestinal strangulation obstruction is a critical condition in horses.
- Understanding the pathological differences between arterial and venous occlusions is vital for diagnosis and treatment.
Purpose of the Study:
- To compare the gross and histological effects of ischemic strangulation obstruction (ISO) and hemorrhagic strangulation obstruction (HSO) in equine jejunum.
- To evaluate the progression of damage over 1, 2, and 3 hours.
Main Methods:
- Arteriovenous (ischemic) and venous (hemorrhagic) occlusions were created in the jejunum of 5 horses.
- Segments were observed grossly for color, thickness, and motility at 1, 2, and 3 hours.
- Histological examination assessed mucosal slough, edema, congestion, and hemorrhage.
Main Results:
- Ischemic strangulation obstruction (ISO) resulted in dark segments without significant edema or hemorrhage.
- Hemorrhagic strangulation obstruction (HSO) caused progressive congestion, edema, and hemorrhage, predominantly in the mucosa.
- Histologically, mucosal epithelium was similarly affected by both ISO and HSO, but gross changes were more pronounced with HSO.
Conclusions:
- Both ISO and HSO induce significant pathological changes in the equine jejunum.
- HSO presents with more pronounced gross pathological alterations compared to ISO.
- Histological damage to the mucosal epithelium is comparable between the two types of obstruction.