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μSonic-hand: Biomedical micromanipulation driven by acoustic gas-liquid-solid interactions.

Xiaoming Liu1, Yuyang Li1,2, Fengyu Liu1

  • 1Key Laboratory of Biomimetic Robots and Systems, Ministry of Education, State Key Laboratory of Intelligent Control and Decision of Complex System, and School of Mechatronical Engineering, Beijing Institute of Technology, Beijing 100081, China.

Science Advances
|March 28, 2025
PubMed
Summary
This summary is machine-generated.

Acoustic interactions enable a new micromanipulation technique, the μSonic-hand, for safe, low-cost bio-object handling. This method offers versatile control for mixing, cell manipulation, and transport across various scales in biomedical applications.

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Area of Science:

  • Biomedical Engineering
  • Acoustics
  • Microfluidics

Background:

  • Micromanipulation is essential for biomedical research and applications.
  • Current methods for micromanipulation are often expensive, lack multifunctionality, or are limited in scope.
  • A need exists for accessible, versatile, and safe micromanipulation techniques for bio-objects.

Purpose of the Study:

  • To introduce a novel, versatile micromanipulation method driven by acoustic gas-liquid-solid interactions.
  • To demonstrate the capabilities of this method for various liquid and bio-object manipulations.
  • To present a low-cost, biocompatible solution for advanced biomedical applications.

Main Methods:

  • Utilized acoustic waves acting on a gas-liquid multiphase system within a micropipette.
  • Employed a piezoelectric transducer to generate acoustic microstreaming and controlled vortices.
  • Applied the technique to manipulate liquids (mixing, dispersion) and bio-objects (HeLa cells, embryos).

Main Results:

  • Achieved efficient mass transfer, enhancing liquid micromanipulations like mixing and cell permeability.
  • Demonstrated stable 3D trapping, rapid transportation, and multidirectional rotation of bio-objects in an open environment.
  • Successfully manipulated objects ranging from micrometers to millimeters, overcoming microfluidic chip limitations.

Conclusions:

  • The μSonic-hand offers a versatile, low-cost, and biocompatible micromanipulation solution.
  • This acoustic-driven method significantly advances capabilities for handling bio-objects across scales.
  • The technology has the potential to broadly impact biomedical science and applications.