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Assessment of Vascular Function in Patients With Chronic Kidney Disease
Published on: June 16, 2014
Status of Lipid Profile among Patients with Chronic Kidney Disease
1Dr Sazia Afrin Mitu, Curator, Department of Pathology, Mymensingh Medical College (MMC), Mymensingh, Bangladesh;
Insights
This study found that patients with chronic kidney disease (CKD) have significantly higher levels of total cholesterol, triglycerides, and LDL cholesterol, along with lower HDL cholesterol, indicating a link between dyslipidemia and CKD progression.
Area of Science:
- Biochemistry
- Nephrology
- Clinical Medicine
Background:
- Chronic kidney disease (CKD) is a global health concern, often caused by diabetes and vascular diseases.
- Effective CKD management involves cardiovascular risk reduction, albuminuria treatment, and avoiding nephrotoxins.
- CKD patients require monitoring for complications like dyslipidemia, anemia, and electrolyte imbalances.
Purpose of the Study:
- To investigate the relationship between lipid profiles and chronic kidney disease.
- To compare serum lipid levels in CKD patients versus healthy individuals.
Main Methods:
- A cross-sectional study involving 120 participants (60 CKD patients, 60 healthy controls).
- Serum lipid profiles (TC, TG, LDL-C, HDL-C) were measured.
- Statistical analysis using SPSS, with Student's unpaired 't' test for significance.
Main Results:
- CKD patients showed significantly increased mean serum total cholesterol (TC), triglyceride (TG), and LDL-cholesterol (LDL-C) levels.
- CKD patients exhibited significantly decreased mean serum HDL-cholesterol (HDL-C) levels compared to controls.
- Specific mean values: TC (149.85±38.84 vs 178.92±41.85 mg/dl), TG (122.77±36.88 vs 175.93±63.50 mg/dl), LDL-C (95.13±24.43 vs 115.60±45.62 mg/dl), HDL-C (48.62±8.70 vs 41.55±2.79 mg/dl) in controls vs CKD patients respectively.
Conclusions:
- The study highlights a significant association between dyslipidemia and chronic kidney disease.
- Altered lipid profiles, specifically elevated LDL and decreased HDL, are prevalent in CKD patients.
- These findings underscore the importance of monitoring and managing lipid abnormalities in CKD management.
Abstract:
Chronic kidney disease (CKD) is an increasing threat for health-care systems in the world. Primary causes of CKD are diabetes and vascular diseases. So, optimal management of CKD includes cardiovascular risk reduction, treatment of albuminuria, avoidance of potential nephrotoxins and adjustments to drug dosing. Patients also require monitoring for complications of CKD, such as hypocalcemia, hyper-kalemia, dyslipidemia, metabolic acidosis, hyper-phosphatemia, vitamin D deficiency, secondary hyper-parathyroidism and anaemia. This cross-sectional study was executed in the Department of Biochemistry, Mymensingh Medical College, in collaboration with the Department of Nephrology, Mymensingh Medical College Hospital, Mymensingh, Bangladesh from July 2022 to June 2023. The subjects were selected based on inclusion and exclusion criteria by purposive non-random sampling. A sum of 120 subjects was included in this study. Out of them, 60 were selected as case of CKD patients and another 60 apparently normal healthy persons were selected as control. In this study, serum lipid profile was measured for analytical study. All the values were showed as mean±SD and these were serum TC were 149.85±38.84 in Group I and 178.92±41.85mg/dl in Group II; Serum TG were 122.77±36.88 in Group I and 175.93±63.50mg/dl in Group II; Serum LDL-C were 95.13±24.43 in Group I and 115.60±45.62 mg/dl in Group II and Serum HDL-C were 48.62±8.70 and 41.55±2.79mg/dl in Group I and Group II respectively. Statistical analysis was done by using statistical package for social science (SPSS), windows package version 26.0. The statistical significance of the difference between the case and control was evaluated using Student's unpaired 't' test. After careful evaluation, the present study found that mean serum total cholesterol (TC), Triglyceride (TG) and Low density lipoprotein (LDL-C) level were significantly increased and High density lipoprotein (HDL-C) level were significantly decreased in CKD patients.
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