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Organelle-oriented nanomedicines in tumor therapy: Targeting, escaping, or collaborating?
Kexin Tan1, Haiyang Zhang1, Jianyuan Yang1
1Department of Ophthalmology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology, and Center for Basic Medical Research and Innovation in Visual System Diseases of Ministry of Education, Shanghai, 200011, PR China.
Abstract:
Precise tumor therapy is essential for improving treatment specificity, enhancing efficacy, and minimizing side effects. Targeting organelles is a key strategy for achieving this goal and is a frontier research area attracting a considerable amount of attention. The concept of organelle targeting has a significant effect on the structural design of the nanodrugs employed. Most notably, the intricate interactions among different organelles in a tumor cell essentially create a unified system. Unfortunately, this aspect might have been somewhat overlooked when existing organelle-targeting nanodrugs were designed. In this review, we underscore the synergistic relationship among the various organelles and advocate for a holistic view of organelle-targeting design. Through the integration of biology and material science, recent advancements in organelle targeting, escaping, and collaborating are consolidated to offer fresh perspectives for the development of antitumor nanomedicines.
Insights
This review highlights the importance of considering the synergistic interactions between tumor cell organelles for designing effective nanomedicines. A holistic approach to organelle targeting can improve precision cancer therapy.
Area of Science:
- Biomedical Engineering
- Nanomedicine
- Cancer Therapy
Background:
- Precise tumor therapy requires enhanced specificity and efficacy while minimizing side effects.
- Organelle targeting is a key strategy in developing advanced nanomedicines for cancer treatment.
- Current nanodrug design may overlook the complex interplay between different organelles within tumor cells.
Purpose of the Study:
- To emphasize the synergistic relationships among tumor cell organelles.
- To advocate for a holistic design strategy in organelle-targeting nanomedicines.
- To consolidate recent advancements in organelle targeting, escaping, and collaboration for antitumor nanomedicines.
Main Methods:
- Review of current literature integrating biology and material science.
- Analysis of organelle interactions within tumor cells.
- Consolidation of recent advancements in nanomedicine for organelle targeting.
Main Results:
- Organelle interactions form a unified system within tumor cells, impacting nanodrug efficacy.
- A holistic approach to nanodrug design considering these interactions is crucial.
- Recent progress offers new perspectives for developing next-generation antitumor nanomedicines.
Conclusions:
- Rethinking nanodrug design to encompass the holistic behavior of tumor cell organelles is essential.
- Integrating insights from biology and material science can drive innovation in precision cancer therapy.
- Future nanomedicines should leverage organelle synergy for improved therapeutic outcomes.
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