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Updated: May 17, 2025

Trans-Tympanic Drug Delivery for the Treatment of Ototoxicity
Published on: March 16, 2018
What's New in Ototoxicity Management?
Katharine A Fernandez1, Angela Garinis2,3, Kristin Knight4
1National Institute on Deafness and Other Communication Disorders, NIH, Bethesda, MD.
Proactive ototoxicity management (OtoM) strategies protect hearing and vestibular health from damaging medications and chemicals. Wider adoption of OtoM services is encouraged to minimize risks and manage auditory changes.
Area of Science:
- Audiology
- Occupational Health
- Toxicology
Background:
- Ototoxic medications and workplace chemicals pose risks to hearing and vestibular health.
- Permanent injury can result from exposure to ototoxic agents.
- Current management strategies require broader implementation.
Purpose of the Study:
- To summarize viewpoints on integrating ototoxicity management (OtoM) into clinical practice.
- To identify tools and considerations for supporting patients undergoing OtoM.
- To encourage widespread adoption of improved OtoM services for at-risk individuals.
Main Methods:
- Discussion among members of the International Ototoxicity Management Group.
- Summarization of expert viewpoints on OtoM integration.
- Review of current practices and future needs in ototoxicity management.
Main Results:
- OtoM strategies aim to minimize exposure, prevent symptom onset, and monitor auditory/vestibular changes.
- Expert consensus was reached on integrating OtoM into routine clinical practice.
- Key considerations for patient and family support were identified.
Conclusions:
- The audiology field needs to expand universal guidelines for mitigating, detecting, and managing ototoxicity.
- A recent therapeutic drug offers protection but is limited to a specific pediatric population.
- Ototoxicity from other agents and in diverse patient groups remains a significant concern.
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