Evaluation of a New Fully Automatic OLCR Biometer: Repeatability, Reproducibility, and Agreement with an SS-OCT...

Area of Science:

• Ophthalmology
• Biomedical Engineering
• Optical Coherence Tomography

Background:

• Accurate biometric measurements are crucial for refractive surgery and intraocular lens (IOL) power calculations.
• The LUS-1000 Plus is a novel fully automatic optical low coherence reflectometry (OLCR)-based biometer.
• Evaluating its performance against established devices is essential for clinical adoption.

Purpose of the Study:

• To assess the intraobserver repeatability and interobserver reproducibility of the LUS-1000 Plus biometer.
• To evaluate the agreement between the LUS-1000 Plus and the IOLMaster 700 for various ocular biometric parameters.
• To determine the reliability and potential interchangeability of the LUS-1000 Plus in clinical practice.

Main Methods:

• A prospective study involving 77 healthy participants' right eyes.
• Measurement of key ocular parameters including axial length (AL), central corneal thickness (CCT), anterior chamber depth (ACD), keratometry (Kf, Ks, Km), astigmatism (AST, J0, J45), and corneal diameter (CD).
• Statistical analysis using within-subject standard deviation (Sw), test-retest repeatability (TRT), coefficient of variation (CoV), intraclass correlation coefficient (ICC), paired t-tests, and Bland-Altman plots.

Main Results:

• The LUS-1000 Plus exhibited high repeatability and reproducibility across all measured parameters, indicated by low Sw, TRT, CoV, and high ICC values.
• Excellent interdevice agreement was observed between the LUS-1000 Plus and IOLMaster 700, with narrow 95% limits of agreement for all parameters.
• Specific limits of agreement were detailed for AL, CCT, AQD, ACD, LT, keratometry, astigmatism, and corneal diameter.

Conclusions:

• The LUS-1000 Plus biometer demonstrates robust repeatability and reproducibility.
• Its excellent agreement with the IOLMaster 700 supports its reliability for clinical use.
• The LUS-1000 Plus is a reliable and potentially interchangeable option with the IOLMaster 700 for ophthalmic biometry.