Related Experiment Video
Updated: May 16, 2025

Author Spotlight: Isolation and Culture of Primary Synovial Macrophages and Fibroblasts from Murine Arthritis Tissue
Published on: February 24, 2023
Juvenile Idiopathic Arthritis and Spondylarthritis
Dov Rosenbaum1,2, Arthur B Meyers3, Patricia Vega-Fernandez4
1Department of Radiology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.
Insights
Juvenile idiopathic arthritis (JIA) is a complex childhood condition with varied symptoms. This review details imaging strategies for common and unique joints affected by JIA, aiding diagnosis and treatment.
Area of Science:
- Pediatric Rheumatology
- Medical Imaging
- Orthopedic Surgery
Background:
- Juvenile idiopathic arthritis (JIA) is a heterogeneous autoimmune disorder affecting children under 16.
- Clinical presentation of JIA is diverse, impacting various joints without a specific predilection.
- Imaging plays a crucial role in diagnosing and monitoring JIA, but approaches vary based on affected joints.
Purpose of the Study:
- To outline a general imaging approach for juvenile idiopathic arthritis (JIA).
- To highlight imaging considerations for typical joints (knee, hand, wrist) and unique sites (temporomandibular, cervical spine, sacroiliac joints) affected by JIA.
- To review anatomical, developmental, and location-specific imaging strategies for JIA management.
Main Methods:
- Review of current literature and established imaging protocols for JIA.
- Case examples illustrating imaging findings in common and unique joints affected by JIA.
- Discussion of multimodal imaging approaches and standardized scoring systems where applicable.
Main Results:
- A systematic imaging approach is essential for diagnosing JIA due to its heterogeneity.
- Specific imaging considerations are required for typical joints like the knee, hand, and wrist.
- Unique joints such as the temporomandibular, cervical spine, and sacroiliac joints require specialized imaging evaluation for JIA.
Conclusions:
- A comprehensive, joint-specific imaging strategy is vital for accurate JIA diagnosis and management.
- Utilizing standardized scoring systems and multimodal imaging enhances diagnostic accuracy.
- Understanding regional anatomy and development is key for interpreting JIA imaging findings in unique joints.
Abstract:
Juvenile idiopathic arthritis (JIA) is a heterogeneous disorder affecting children < 16 years of age. The clinical heterogeneity translates to imaging, where no specific joint is affected. This article highlights a general imaging approach to JIA, using specific examples of the knee, hand, and wrist as the typical joints affected. We then focus on unique joints that are commonly affected by JIA: the temporomandibular joint, the joints of the upper cervical spine, and the sacroiliac joint. For these latter anatomical sites, regional anatomy and development, location-specific imaging considerations, and arthritis, treatment decision making, and potential differential considerations are reviewed. We highlight, where applicable, a multimodal approach to imaging using developed or developing standardized scoring systems.
Related Concept Videos
Autoimmune Disorders
Concept and Mechanism of Autoimmune Diseases
The immune...
The JAK-STAT Signaling Pathway
Genome-wide Association Studies-GWAS
GWAS does not require the identification of the target gene involved in...
Structural Joints: Synovial Joints
Functional Classification of Joints
The functional classification of joints is determined by the amount of mobility between the adjacent bones. Joints are functionally classified as a synarthrosis or immobile joint, an amphiarthrosis or slightly moveable joint, or as a diarthrosis, a freely moveable joint. Fibrous and cartilaginous joints can be functionally classified as either synarthroses or amphiarthroses, whereas all synovial joints are classified as diarthroses.
Synarthrosis
An...
Development of the Limb Synovial Joints
The mesenchymal stem cells differentiate into chondrocytes that form the hyaline cartilage, and later the cartilaginous model of the bone. This model further transforms into a bone. This process is known as endochondral ossification.
During development, the limbs...

