Renal glomerulopathies associated with Hodgkin's disease

From a series of 138 patients with Hodgkin's disease seen over a 17-year period, 2 developed the nephrotic syndrome. One patient developed hematuria unrelated to cytotoxic chemotherapy or thrombocytopenia. All three patients had evidence of glomerulopathy on histologic examination of renal tissue, but none had the more usually associated minimal-change glomerular histologic features. The patients with nephrotic syndrome had effective clinical regression with systemic chemotherapy. The significance of renal glomerular disease in association with Hodgkin's disease is discussed.