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Proteomics

Proteomics

A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term...

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Related Experiment Video

Updated: May 8, 2025

TMT Sample Preparation for Proteomics Facility Submission and Subsequent Data Analysis

TMT Sample Preparation for Proteomics Facility Submission and Subsequent Data Analysis

Published on: June 8, 2020

High Throughput Proteomics Using the SomaLogic Platform.

Hanjun Zhao¹, Laura Winchester²

¹Department of Psychiatry, University of Oxford, Oxford, UK.

Methods in Molecular Biology (Clifton, N.J.)

|April 1, 2025

Summary

This summary is machine-generated.

SomaLogic's SOMAscan platform offers high-throughput protein measurement using Slow Off-rate Modified Aptamer (SOMAmer) reagents. This proteomics technology precisely quantifies thousands of proteins across various biological samples.

Keywords:

Aptamer Differential expression Pathway Somalogic

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Area of Science:

Proteomics and Biotechnology
Biomarker Discovery and Validation

Background:

High-throughput protein measurement is crucial for biological research and diagnostics.
Existing methods include affinity-based assays and unbiased mass spectrometry.
SomaLogic's SOMAscan platform represents an advanced affinity-based approach.

Purpose of the Study:

To introduce and describe SomaLogic's SOMAscan platform for protein measurement.
To highlight the capabilities of the SOMAscan platform in terms of multiplexing, sensitivity, and throughput.
To detail the underlying technology utilizing SOMAmer reagents.

Main Methods:

Utilizes Slow Off-rate Modified Aptamer (SOMAmer) reagents for protein binding.
Employs a highly multiplexed assay capable of measuring thousands of proteins simultaneously.
Applicable to various biological fluid samples, including CSF, plasma, and serum.

Main Results:

The SOMAscan platform enables precise, quantitative, and reproducible protein measurements.
Achieves high-throughput analysis, measuring proteins rapidly.
Demonstrates broad coverage (thousands of proteins) and deep quantification (high- and low-abundance proteins).

Conclusions:

The SOMAscan platform is a cutting-edge proteomics technology for comprehensive protein analysis.
Its sensitivity, throughput, and reproducibility make it suitable for diverse biological applications.
SOMAmer-based aptamers offer a powerful tool for advancing proteomic research.