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Raman Optical Activity Enhanced via Supramolecular Aggregation and Other Intermolecular Interactions-A Review.
Katarzyna Pajor1,2, Monika Halat3, Joanna E Rode4
1Faculty of Chemistry, Jagiellonian University, Gronostajowa 2, 30-387, Krakow, Poland.
Chemistry (Weinheim an Der Bergstrasse, Germany)
|April 1, 2025
Summary
Raman optical activity (ROA) and electronic circular dichroism (ECD) detect supramolecular chirality, amplification, and transfer. Carotenoid aggregation revealed new ROA phenomena and natural chirality induction.
Area of Science:
- Chiroptical spectroscopy
- Supramolecular chemistry
- Vibrational optical activity
Background:
- Vibrational optical activity (VOA) has seen significant advancements in studying spontaneous self-organization.
- Chirality detection in supramolecular systems is crucial for understanding molecular interactions.
Purpose of the Study:
- To review the effectiveness of Raman optical activity (ROA) and electronic circular dichroism (ECD) in detecting supramolecular chirality.
- To explore chiral signal amplification and chirality transfer mechanisms.
- To discuss novel phenomena in ROA, including aggregation-induced resonance Raman optical activity (AIRROA).
Main Methods:
- Combined application of Raman optical activity (ROA) and electronic circular dichroism (ECD).
- Analysis of carotenoid aggregation pathways.
- Investigation of chiroptical properties in complex systems like amyloid fibrils and plasmonic nanoparticles.
Main Results:
- ROA and ECD effectively detect supramolecular chirality, amplification, and transfer.
- Carotenoid aggregation leads to phenomena like AIRROA and natural chirality induction.
- ROA signal enhancement observed in amyloid fibrils and plasmon-supported aggregates.
Conclusions:
- ROA and ECD are powerful tools for analyzing supramolecular chirality and related processes.
- Carotenoids serve as a model system for studying amplification, induction, and transfer of chirality.
- Challenges remain in interpreting ROA signals for strongly absorbing compounds due to potential artifacts.
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