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Requirements and Study Design for the Next Proton FLASH Clinical Trials: an International Multidisciplinary Delphi

Yvonne L B Klaver1, Mischa S Hoogeman2, Q Richard Lu3

  • 1HollandPTC, Delft, The Netherlands; Department of Radiotherapy, Leiden University Medical Center, Leiden, The Netherlands.

International Journal of Radiation Oncology, Biology, Physics
|April 2, 2025
PubMed
Summary

Proton FLASH (pFLASH) irradiation shows promise for sparing normal tissues while controlling tumors. Expert consensus recommends preclinical validation and toxicity reduction as primary endpoints for future clinical trials, with specific patient and setting guidelines.

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