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Risk factors for cholera mortality: A scoping review.

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Summary
This summary is machine-generated.

Cholera remains a significant global health threat, causing preventable deaths. This review identifies key risk factors for cholera mortality, including patient characteristics like age and sex, to improve case management.

Keywords:
case fatalitycholeracholera mortalityrisk factorsscoping reviewvibrio cholerae

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Area of Science:

  • Epidemiology
  • Infectious Diseases
  • Public Health

Background:

  • Cholera, a waterborne disease, continues to cause significant mortality globally despite being treatable.
  • Understanding risk factors for cholera mortality is crucial for improving case management and reducing deaths.
  • A comprehensive review of existing literature is needed to identify these risk factors.

Purpose of the Study:

  • To conduct a scoping review to explore and summarize evidence on cholera mortality.
  • To identify and categorize the most common risk factors associated with cholera-related deaths.

Main Methods:

  • A scoping review was performed following the Arksey and O'Malley framework.
  • Searches were conducted across multiple databases (PubMed, EMBASE, Web of Science, LILACS, Scielo, Cochrane, Open Grey, African Journals Online) without date or language restrictions.
  • Thematic analysis was applied to the data extracted from 77 included studies.

Main Results:

  • Seventy-seven studies were included, categorizing risk factors into patient characteristics, healthcare, and health-seeking behavior.
  • Higher case fatality ratios were observed in males and individuals aged 50 and above.
  • A significant proportion of deaths (23%-96%) occurred in the community, indicating challenges in healthcare access or timely intervention.

Conclusions:

  • Limited published evidence exists on factors increasing cholera-related death risk.
  • Collecting and analyzing baseline patient data (age, sex, predisposing conditions) is essential for understanding mortality.
  • Improved data collection can guide better case management recommendations and reduce cholera mortality.